Formulation and characterization of drug-loaded nanocarriers modified resin-based systems for applications in adhesive dentistry

Zohaib Akram

doi:10.26182/r596-4g10

Formulation and characterization of drug-loaded nanocarriers modified resin-based systems for applications in adhesive dentistry

Zohaib Akram

Dental School

Research output: Thesis › Master's Thesis

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Abstract

We formulated a pH-sensitive chlorhexidine-loaded mesoporous silica nanoparticles (MSN) modified with poly-(lactic-co-glycolic acid) (CHX-loaded/MSN-PLGA) and graphene nanoparticles incorporated into experimental resin-based dentin adhesives. Nanocarriers were characterized for morphology, physicochemical features, spectral analyses, drug-release kinetics at varying pH and its effect on dentin-bound proteases was investigated. The modified dentin adhesives were characterized for cytotoxicity, antimicrobial activity, degree of conversion (DC), micro-tensile bond strength (µTBS) and nano-leakage expression were studied at different pH values and storage time. The addition of graphene nanoparticles and CHX-MSN showed optimized DC, antibiofilm activity, and micro-tensile bond strength without affecting the standard adhesion characteristics.

Original language	English
Qualification	Masters
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Fawzy Moussa, Amr, Supervisor Baker, Murray, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	29 Nov 2024
DOIs	https://doi.org/10.26182/r596-4g10
Publication status	Unpublished - 2024

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10.26182/r596-4g10

THESIS - MASTER OF PHILOSOPHY - AKRAM Zohaib - 2024
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4 Article

Formulation of nano-graphene doped with nano silver modified dentin bonding agents with enhanced interfacial stability and antibiofilm properties
Akram, Z., Aati, S., Clode, P., Saunders, M., Ngo, H. & Fawzy, A. S., Feb 2022, In: Dental Materials. 38, 2, p. 347-362 16 p.
Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus)
Formulation of pH-sensitive chlorhexidine-loaded/mesoporous silica nanoparticles modified experimental dentin adhesive
Akram, Z., Daood, U., Aati, S., Ngo, H. & Fawzy, A. S., Mar 2021, In: Materials Science and Engineering C. 122, 111894.
Research output: Contribution to journal › Article › peer-review
50 Citations (Scopus)
pH-dependent delivery of chlorhexidine from PGA grafted mesoporous silica nanoparticles at resin-dentin interface
Akram, Z., Aati, S., Ngo, H. & Fawzy, A., Dec 2021, In: Journal of Nanobiotechnology. 19, 1, p. 43 43.
Research output: Contribution to journal › Article › peer-review

Open Access
49 Citations (Web of Science)

Cite this

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title = "Formulation and characterization of drug-loaded nanocarriers modified resin-based systems for applications in adhesive dentistry",

abstract = "We formulated a pH-sensitive chlorhexidine-loaded mesoporous silica nanoparticles (MSN) modified with poly-(lactic-co-glycolic acid) (CHX-loaded/MSN-PLGA) and graphene nanoparticles incorporated into experimental resin-based dentin adhesives. Nanocarriers were characterized for morphology, physicochemical features, spectral analyses, drug-release kinetics at varying pH and its effect on dentin-bound proteases was investigated. The modified dentin adhesives were characterized for cytotoxicity, antimicrobial activity, degree of conversion (DC), micro-tensile bond strength (µTBS) and nano-leakage expression were studied at different pH values and storage time. The addition of graphene nanoparticles and CHX-MSN showed optimized DC, antibiofilm activity, and micro-tensile bond strength without affecting the standard adhesion characteristics.",

keywords = "Dentin bonding, chlorhexidine, mesoporous silica, graphene, nanoparticles, adhesives",

author = "Zohaib Akram",

year = "2024",

doi = "10.26182/r596-4g10",

language = "English",

school = "The University of Western Australia",

}

TY - THES

T1 - Formulation and characterization of drug-loaded nanocarriers modified resin-based systems for applications in adhesive dentistry

AU - Akram, Zohaib

PY - 2024

Y1 - 2024

N2 - We formulated a pH-sensitive chlorhexidine-loaded mesoporous silica nanoparticles (MSN) modified with poly-(lactic-co-glycolic acid) (CHX-loaded/MSN-PLGA) and graphene nanoparticles incorporated into experimental resin-based dentin adhesives. Nanocarriers were characterized for morphology, physicochemical features, spectral analyses, drug-release kinetics at varying pH and its effect on dentin-bound proteases was investigated. The modified dentin adhesives were characterized for cytotoxicity, antimicrobial activity, degree of conversion (DC), micro-tensile bond strength (µTBS) and nano-leakage expression were studied at different pH values and storage time. The addition of graphene nanoparticles and CHX-MSN showed optimized DC, antibiofilm activity, and micro-tensile bond strength without affecting the standard adhesion characteristics.

AB - We formulated a pH-sensitive chlorhexidine-loaded mesoporous silica nanoparticles (MSN) modified with poly-(lactic-co-glycolic acid) (CHX-loaded/MSN-PLGA) and graphene nanoparticles incorporated into experimental resin-based dentin adhesives. Nanocarriers were characterized for morphology, physicochemical features, spectral analyses, drug-release kinetics at varying pH and its effect on dentin-bound proteases was investigated. The modified dentin adhesives were characterized for cytotoxicity, antimicrobial activity, degree of conversion (DC), micro-tensile bond strength (µTBS) and nano-leakage expression were studied at different pH values and storage time. The addition of graphene nanoparticles and CHX-MSN showed optimized DC, antibiofilm activity, and micro-tensile bond strength without affecting the standard adhesion characteristics.

KW - Dentin bonding

KW - chlorhexidine

KW - mesoporous silica

KW - graphene

KW - nanoparticles

KW - adhesives

U2 - 10.26182/r596-4g10

DO - 10.26182/r596-4g10

M3 - Master's Thesis

ER -

Formulation and characterization of drug-loaded nanocarriers modified resin-based systems for applications in adhesive dentistry

Abstract

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Research output

Formulation of nano-graphene doped with nano silver modified dentin bonding agents with enhanced interfacial stability and antibiofilm properties

Formulation of pH-sensitive chlorhexidine-loaded/mesoporous silica nanoparticles modified experimental dentin adhesive

pH-dependent delivery of chlorhexidine from PGA grafted mesoporous silica nanoparticles at resin-dentin interface

Cite this