Forensic applications of the genomic matching technique: Profiling the alpha block in the major histocompatibility complex

R. Laird; R. L. Dawkins; N. Jacobsen; S. Gaudieri

doi:10.1016/S0531-5131(03)01706-0

Forensic applications of the genomic matching technique: Profiling the alpha block in the major histocompatibility complex

R. Laird
, R. L. Dawkins
, N. Jacobsen
, S. Gaudieri

School of Human Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The genomic matching technique (GMT) was developed to characterize polymorphic sequences within the human major histocompatibility complex (MHC), known as polymorphic frozen blocks (PFBs). PFBs are 200–300 kb sequences containing duplications, indels and SNPs. The power of the GMT to differentiate between individuals at the DNA level means that it can be applied as an exclusion tool in forensic science. Here, the GMT is applied to the alpha block in the MHC.

Original language	English
Pages (from-to)	580-582
Number of pages	3
Journal	International Congress Series
Volume	1261
Issue number	C
DOIs	https://doi.org/10.1016/S0531-5131(03)01706-0
Publication status	Published - 1 Apr 2004

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abstract = "The genomic matching technique (GMT) was developed to characterize polymorphic sequences within the human major histocompatibility complex (MHC), known as polymorphic frozen blocks (PFBs). PFBs are 200–300 kb sequences containing duplications, indels and SNPs. The power of the GMT to differentiate between individuals at the DNA level means that it can be applied as an exclusion tool in forensic science. Here, the GMT is applied to the alpha block in the MHC.",

keywords = "Alpha block, Ancestral haplotypes, Genomic matching technique, Major histocompatibility complex, Polymorphic frozen block",

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AU - Dawkins, R. L.

AU - Jacobsen, N.

AU - Gaudieri, S.

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AB - The genomic matching technique (GMT) was developed to characterize polymorphic sequences within the human major histocompatibility complex (MHC), known as polymorphic frozen blocks (PFBs). PFBs are 200–300 kb sequences containing duplications, indels and SNPs. The power of the GMT to differentiate between individuals at the DNA level means that it can be applied as an exclusion tool in forensic science. Here, the GMT is applied to the alpha block in the MHC.

KW - Alpha block

KW - Ancestral haplotypes

KW - Genomic matching technique

KW - Major histocompatibility complex

KW - Polymorphic frozen block

UR - https://www.scopus.com/pages/publications/85023116417

U2 - 10.1016/S0531-5131(03)01706-0

DO - 10.1016/S0531-5131(03)01706-0

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JO - International Congress Series

JF - International Congress Series

IS - C

ER -

Forensic applications of the genomic matching technique: Profiling the alpha block in the major histocompatibility complex

Abstract

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