TY - JOUR
T1 - Forensic applications of the genomic matching technique
T2 - Profiling the alpha block in the major histocompatibility complex
AU - Laird, R.
AU - Dawkins, R. L.
AU - Jacobsen, N.
AU - Gaudieri, S.
PY - 2004/4/1
Y1 - 2004/4/1
N2 - The genomic matching technique (GMT) was developed to characterize polymorphic sequences within the human major histocompatibility complex (MHC), known as polymorphic frozen blocks (PFBs). PFBs are 200–300 kb sequences containing duplications, indels and SNPs. The power of the GMT to differentiate between individuals at the DNA level means that it can be applied as an exclusion tool in forensic science. Here, the GMT is applied to the alpha block in the MHC.
AB - The genomic matching technique (GMT) was developed to characterize polymorphic sequences within the human major histocompatibility complex (MHC), known as polymorphic frozen blocks (PFBs). PFBs are 200–300 kb sequences containing duplications, indels and SNPs. The power of the GMT to differentiate between individuals at the DNA level means that it can be applied as an exclusion tool in forensic science. Here, the GMT is applied to the alpha block in the MHC.
KW - Alpha block
KW - Ancestral haplotypes
KW - Genomic matching technique
KW - Major histocompatibility complex
KW - Polymorphic frozen block
UR - http://www.scopus.com/inward/record.url?scp=85023116417&partnerID=8YFLogxK
U2 - 10.1016/S0531-5131(03)01706-0
DO - 10.1016/S0531-5131(03)01706-0
M3 - Article
AN - SCOPUS:85023116417
SN - 0531-5131
VL - 1261
SP - 580
EP - 582
JO - International Congress Series
JF - International Congress Series
IS - C
ER -