TY - JOUR
T1 - Follicle-stimulating hormone (FSHβ) gene polymorphisms and associations with reproductive traits in Rex rabbits
AU - Niu, Xiaoyan
AU - Martin, Graeme B.
AU - Liu, Wenzhong
AU - Henryon, Mark A.
AU - Ren, Keliang
PY - 2019/8
Y1 - 2019/8
N2 - Follicle-stimulating hormone (FSH) stimulates granulosa cell proliferation and controls the development and maturation of oocytes. In this study with Rex rabbit, there was exploration of the relationships between reproductive traits and SNPs and haplotypes of FSHβ, and tested whether FSHβ SNPs would segregate between two lines, using 70 females from the White line and 100 females from the Beaver line. Three SNPs (FSH2, FSH30, FSH31) in exon1 and exon3 of FSHβ were strongly associated with reproductive traits in the combined population. For FSH2, the GG variant was associated with greater (P < 0.05) values for total number born (TNB) and number born alive (NBA), compared to those with the TT variant. For FSH30, for the AA variant there was greater (P < 0.05) values for TNB and NBA than with the GG and AG variants. For FSH31, the GG variant was associated with greater (P < 0.05) values for TNB, litter weight at birth (LWB) and litter size at 21 days of age (LS21), than the AG variant, and with greater (P < 0.01) values for NBA than the AG variant. When analyzed separately, FSH2 SNP was associated with LW21 in the Beaver line (P < 0.05), whereas FSH30 and FSH31 SNPs were associated with TNB and NBA in the White line (P < 0.05). It is concluded that genetic variation in FSHβ gene is associated with reproductive traits in the Rex rabbit, therefore, the FSH2, FSH30 and FSH31 SNPs can be used as molecular markers in genetic selection of rabbits.
AB - Follicle-stimulating hormone (FSH) stimulates granulosa cell proliferation and controls the development and maturation of oocytes. In this study with Rex rabbit, there was exploration of the relationships between reproductive traits and SNPs and haplotypes of FSHβ, and tested whether FSHβ SNPs would segregate between two lines, using 70 females from the White line and 100 females from the Beaver line. Three SNPs (FSH2, FSH30, FSH31) in exon1 and exon3 of FSHβ were strongly associated with reproductive traits in the combined population. For FSH2, the GG variant was associated with greater (P < 0.05) values for total number born (TNB) and number born alive (NBA), compared to those with the TT variant. For FSH30, for the AA variant there was greater (P < 0.05) values for TNB and NBA than with the GG and AG variants. For FSH31, the GG variant was associated with greater (P < 0.05) values for TNB, litter weight at birth (LWB) and litter size at 21 days of age (LS21), than the AG variant, and with greater (P < 0.01) values for NBA than the AG variant. When analyzed separately, FSH2 SNP was associated with LW21 in the Beaver line (P < 0.05), whereas FSH30 and FSH31 SNPs were associated with TNB and NBA in the White line (P < 0.05). It is concluded that genetic variation in FSHβ gene is associated with reproductive traits in the Rex rabbit, therefore, the FSH2, FSH30 and FSH31 SNPs can be used as molecular markers in genetic selection of rabbits.
KW - Association
KW - Follicle-stimulating hormone
KW - Reproduction
KW - Rex rabbit
UR - http://www.scopus.com/inward/record.url?scp=85067238822&partnerID=8YFLogxK
U2 - 10.1016/j.anireprosci.2019.05.013
DO - 10.1016/j.anireprosci.2019.05.013
M3 - Article
C2 - 31213331
AN - SCOPUS:85067238822
SN - 0378-4320
VL - 207
SP - 36
EP - 43
JO - Animal Reproduction Science
JF - Animal Reproduction Science
ER -