Focus on O-phosphohydroxylysine, O-phosphohydroxyproline, N1-phosphotryptophan and S-phosphocysteine

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The synthesis and chemistry of the lesser-known phosphoamino acids, O-phosphohydroxylysine, O-phosphohydroxyproline, N1-phosphotryptophan and S-phosphocysteine are described in detail. In addition, where anything at all is known, the biological synthesis, occurrence and functions of these phosphoamino acids are described. Of these phosphoamino acids, only N1-phosphotryptophan has not been reported to occur in proteins; however, apart from the roles of S-phosphocysteine in the sugar transporter component (EII) and in catalysis by protein phosphotyrosine phosphatase, little is currently known about the biological roles of the phosphoamino acids when they occur as post-translational modifications.

Original languageEnglish
Pages (from-to)1309-1323
Number of pages15
JournalAmino Acids
Volume49
Issue number8
DOIs
Publication statusPublished - 1 Aug 2017

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Phosphoamino Acids
Protein Tyrosine Phosphatases
Phosphoprotein Phosphatases
Post Translational Protein Processing
Catalysis
Sugars
Proteins
O-phosphohydroxylysine
S-phosphocysteine

Cite this

@article{2b186767b06242318348a3f571c6ca41,
title = "Focus on O-phosphohydroxylysine, O-phosphohydroxyproline, N1-phosphotryptophan and S-phosphocysteine",
abstract = "The synthesis and chemistry of the lesser-known phosphoamino acids, O-phosphohydroxylysine, O-phosphohydroxyproline, N1-phosphotryptophan and S-phosphocysteine are described in detail. In addition, where anything at all is known, the biological synthesis, occurrence and functions of these phosphoamino acids are described. Of these phosphoamino acids, only N1-phosphotryptophan has not been reported to occur in proteins; however, apart from the roles of S-phosphocysteine in the sugar transporter component (EII) and in catalysis by protein phosphotyrosine phosphatase, little is currently known about the biological roles of the phosphoamino acids when they occur as post-translational modifications.",
keywords = "Phosphocysteine, Phosphohydroxylysine, Phosphohydroxyproline, Phosphotryptophan",
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language = "English",
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}

Focus on O-phosphohydroxylysine, O-phosphohydroxyproline, N1-phosphotryptophan and S-phosphocysteine. / Piggott, Matthew J.; Attwood, Paul V.

In: Amino Acids, Vol. 49, No. 8, 01.08.2017, p. 1309-1323.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Focus on O-phosphohydroxylysine, O-phosphohydroxyproline, N1-phosphotryptophan and S-phosphocysteine

AU - Piggott, Matthew J.

AU - Attwood, Paul V.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - The synthesis and chemistry of the lesser-known phosphoamino acids, O-phosphohydroxylysine, O-phosphohydroxyproline, N1-phosphotryptophan and S-phosphocysteine are described in detail. In addition, where anything at all is known, the biological synthesis, occurrence and functions of these phosphoamino acids are described. Of these phosphoamino acids, only N1-phosphotryptophan has not been reported to occur in proteins; however, apart from the roles of S-phosphocysteine in the sugar transporter component (EII) and in catalysis by protein phosphotyrosine phosphatase, little is currently known about the biological roles of the phosphoamino acids when they occur as post-translational modifications.

AB - The synthesis and chemistry of the lesser-known phosphoamino acids, O-phosphohydroxylysine, O-phosphohydroxyproline, N1-phosphotryptophan and S-phosphocysteine are described in detail. In addition, where anything at all is known, the biological synthesis, occurrence and functions of these phosphoamino acids are described. Of these phosphoamino acids, only N1-phosphotryptophan has not been reported to occur in proteins; however, apart from the roles of S-phosphocysteine in the sugar transporter component (EII) and in catalysis by protein phosphotyrosine phosphatase, little is currently known about the biological roles of the phosphoamino acids when they occur as post-translational modifications.

KW - Phosphocysteine

KW - Phosphohydroxylysine

KW - Phosphohydroxyproline

KW - Phosphotryptophan

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JO - Amino Acids

JF - Amino Acids

SN - 0939-4451

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ER -