fMRI findings in an aphasic patient with reversed cerebral dominance for language

Everhard J. M. Vandervliet, Jo Verhoeven, Sebastiaan Engelborghs, Peter Paul De Deyn, Paul M. Parizel, Peter Marien

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


An 80-year-old right-handed woman with no history of brain damage or familial strain of left-handedness acutely developed aphasia associated with a left hemiparesis following a right hemisphere stroke. Brain MRI showed a posterior insular ischemic infarction extending to the temporo-parietal region of the right hemisphere. Severe overall language disruption (global aphasia) in the acute phase of the stroke rapidly evolved into conduction aphasia, characterized by a neurolinguistic profile of disproportionately severe repetition deficits and markedly distorted phonological skills. In the lesion phase of the stroke, a functional MRI study using a word repetition task was conducted which revealed a consistent pattern of right hemisphere activations. For the first time, right hemisphere language dominance is demonstrated by fMRI in a clear instance of crossed aphasia in a dextral.

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalActa Neurologica Belgica
Issue number4
Publication statusPublished - Dec 2008
Externally publishedYes


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