Flexible chitin films as potential wound-dressing materials: wound model studies

N.L.B.M. Yusof, A. Wee, Lee Yong Lim, E. Khor

    Research output: Contribution to journalArticle

    103 Citations (Scopus)

    Abstract

    Chitin films possessing increased flexibility, softness,transparency, and conformability have been prepared.These attributes enable the potential application of chitinfilms as occlusive, semipermeable film wound dressingssimilar to commercial products such as Opsite™. The chitinfilms are generally nonabsorbent, exhibiting a total weightgain of only up to 120–160% in physiological fluid. Drychitin films transpire water vapor at a rate of about 600g/m2/24 h, similar to commercial polyurethane-based filmdressings, but rises to 2400 g/m2/24 h, when wet, which ishigher than the water vapor transmission rate of intact skin.The chitin films are nontoxic to human skin fibroblasts,maintaining 70–80% cell viability. Wound studies using arat model showed no signs of allergenicity or the highinflammatory response associated with biodegradable biomaterials.The chitin films displayed accelerated woundhealingproperties. Based on histological examination,wound sites dressed with the chitin films stabilized andhealed faster, and appeared stronger than those dressedwith Opsite™ and gauze dressings after 7 days of healing.© 2003 Wiley Periodicals, Inc. J Biomed Mater Res 66A:224–232, 2003
    Original languageEnglish
    Pages (from-to)224-232
    JournalJournal of Biomedical Materials Research Part A
    Volume66A
    Issue number2
    Publication statusPublished - 2003

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