Flagellum-mediated adhesion by Burkholderia pseudomallei precedes invasion of Acanthamoeba astronyxis

Tim Inglis, T. Robertson, D.E. Woods, N. Dutton, Barbara Chang

    Research output: Contribution to journalArticle

    43 Citations (Scopus)

    Abstract

    In this study we investigated the role of the bacterial flagellum in Burkholderia pseudomallei entry to Acanthamoeba astronyxis trophozoites. B. pseudomallei cells were tethered to the external amoebic surface via their flagella. MM35, the flagellum-lacking fliC knockout derivative of B. pseudomallei NCTC 1026b did not demonstrate flagellum-mediated endocytosis in timed coculture, confirming that an intact flagellar apparatus assists B. pseudomallei entry into A. astronyxis.
    Original languageEnglish
    Pages (from-to)2280-2282
    JournalInfection and Immunity
    Volume71
    Issue number4
    DOIs
    Publication statusPublished - 2003

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