Flagellum-mediated adhesion by Burkholderia pseudomallei precedes invasion of Acanthamoeba astronyxis

Tim Inglis, T. Robertson, D.E. Woods, N. Dutton, Barbara Chang

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

In this study we investigated the role of the bacterial flagellum in Burkholderia pseudomallei entry to Acanthamoeba astronyxis trophozoites. B. pseudomallei cells were tethered to the external amoebic surface via their flagella. MM35, the flagellum-lacking fliC knockout derivative of B. pseudomallei NCTC 1026b did not demonstrate flagellum-mediated endocytosis in timed coculture, confirming that an intact flagellar apparatus assists B. pseudomallei entry into A. astronyxis.
Original languageEnglish
Pages (from-to)2280-2282
JournalInfection and Immunity
Volume71
Issue number4
DOIs
Publication statusPublished - 2003

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