Fish oil supplementation in pregnancy lowers F2-isoprostanes in neonates at high risk of atopy

Anne Barden, Trevor Mori, Janet Dunstan, A.L. Taylor, C.A. Thornton, Kevin Croft, Lawrence Beilin, Susan Prescott

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)

Abstract

The anti-inflammatory properties of n-3 polyunsaturated fatty acids (n-3 PUFA) have suggested a potential role of these nutrients in dietary modification for prevention of allergic disease in early life. As oxidative stress is known to modify antigen presenting cell (APC) signalling and resulting immune responses, we examined the effects of maternal n-3 PUFA supplementation in pregnancy on markers of oxidative stress and APC function in neonates at high risk of allergy.Eighty-three pregnant atopic women were randomised to receive 4 g daily of either fish oil (n=40) or olive oil (n=43) capsules in a controlled trial from 20 weeks gestation until delivery. Plasma (cord blood) and urinary F2-isoprostanes were measured as markers of lipid peroxidation. Cord erythrocyte fatty acids and markers of APC function (HLA-DR expression and cytokine responses) were measured and related to levels of plasma F2-isoprostanes.Maternal fish oil supplementation lowered plasma (p
Original languageEnglish
Pages (from-to)233-239
JournalFree Radical Research
Volume38
Issue number3
DOIs
Publication statusPublished - 2004

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