First Report of Elevated Monocyte-Platelet Aggregates in Healthy Children

C. Yip, V. Ignjatovic, C. Attard, P. Monagle, Matthew Linden

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Platelets are subcellular fragments which circulate in blood and have well established roles in thrombosis and haemostasis in adults. Upon activation, platelets undergo granule exocytosis and express P-Selectin on the cell membrane which binds a ligand on monocytes, leading to monocyte-platelet aggregation. Elevated circulating monocyte-platelet aggregates in adults are linked to atherothrombosis, but have not been investigated in children where thrombosis is less common. This study aimed to measure monocyte-platelet aggregate formation in children using whole blood flow cytometry. Monocyte-platelet aggregates as well as activation and granule exocytosis of platelets were measured in healthy adults (n = 15, median age 28 years) and healthy children (n = 28, median age 7 years). Monocyte-platelet aggregates in healthy children were elevated compared to healthy adults (37.8±4.4% vs 15.5±1.9% respectively, p
Original languageEnglish
Pages (from-to)5pp
JournalPLoS One
Volume8
Issue number6
DOIs
Publication statusPublished - 2013

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