Fetal growth trajectories and their association with cardiometabolic risk in young adults

Ashish Yadav

doi:10.26182/725v-0w87

Fetal growth trajectories and their association with cardiometabolic risk in young adults

Ashish Yadav

UWA Medical School

Research output: Thesis › Doctoral Thesis

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Abstract

The thesis is based on the concept of developmental origins of health and diseases. Using the RaineStudy data, fetal growth trajectories based on serial pregnancy ultrasound were developed and investigated for their relationship with cardiometabolic risk factors in the adult offspring at 20, 22, and 27 years. Significant associations were found between fetal growth and offspring blood pressure, adiposity, inflammation, and insulin resistance during adulthood. The findings strengthen our understanding of the importance of the intrauterine environment and its effect on the risk of predisposition to adult cardiometabolic diseases.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Beilin, Lawrence, Supervisor Mori, Trevor, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	7 Jun 2024
DOIs	https://doi.org/10.26182/725v-0w87
Publication status	Unpublished - 2024

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THESIS - DOCTOR OF PHILOSOPHY - YADAV Ashish - 2024_
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AB - The thesis is based on the concept of developmental origins of health and diseases. Using the RaineStudy data, fetal growth trajectories based on serial pregnancy ultrasound were developed and investigated for their relationship with cardiometabolic risk factors in the adult offspring at 20, 22, and 27 years. Significant associations were found between fetal growth and offspring blood pressure, adiposity, inflammation, and insulin resistance during adulthood. The findings strengthen our understanding of the importance of the intrauterine environment and its effect on the risk of predisposition to adult cardiometabolic diseases.

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KW - pregnancy

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Fetal growth trajectories and their association with cardiometabolic risk in young adults

Abstract

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