Abstract
metabolism are central in AD pathogenesis. This review has described many of the lipid-related changes that occur in AD, demonstrating the wide range of such changes and, in some cases, listing potential therapeutic treatments. Reducing the risk of AD will involve dietary changes and healthy lifestyles that can reduce the risk of dyslipidaemia, insulin resistance, type 2 diabetes, cardiovascular disease, and chronic inflammation, which are all known risk factors for AD. Despite the many studies on the influence of the APOE 휀4 allele on Aβ aggregation, binding, and clearance, the overall pathological effect of this allele is still not known. Further studies will consolidate these
findings and hopefully clarify which changes in lipid metabolism are most relevant in AD pathogenesis. It is hoped this will pave the way towards effective treatments, whilst highlighting the importance of preventing dyslipidaemia.
| Original language | English |
|---|---|
| Title of host publication | Neurodegeneration and Alzheimer's Disease |
| Place of Publication | London |
| Publisher | John Wiley & Sons |
| Chapter | 7 |
| Pages | 189-231 |
| Edition | 1 |
| ISBN (Print) | 9781119356783 |
| Publication status | Published - 1 May 2019 |
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Fat and Lipid Metabolism and the Involvement of Apolipoprotein E in Alzheimer's Disease. / Hone, Eugene; Lim, Florence; Martins, Ian.
Neurodegeneration and Alzheimer's Disease. 1. ed. London : John Wiley & Sons, 2019. p. 189-231.Research output: Chapter in Book/Conference paper › Chapter
TY - CHAP
T1 - Fat and Lipid Metabolism and the Involvement of Apolipoprotein E in Alzheimer's Disease
AU - Hone, Eugene
AU - Lim, Florence
AU - Martins, Ian
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Lipidomics and genomics studies have made it very clear that lipids and theirmetabolism are central in AD pathogenesis. This review has described many of the lipid-related changes that occur in AD, demonstrating the wide range of such changes and, in some cases, listing potential therapeutic treatments. Reducing the risk of AD will involve dietary changes and healthy lifestyles that can reduce the risk of dyslipidaemia, insulin resistance, type 2 diabetes, cardiovascular disease, and chronic inflammation, which are all known risk factors for AD. Despite the many studies on the influence of the APOE 휀4 allele on Aβ aggregation, binding, and clearance, the overall pathological effect of this allele is still not known. Further studies will consolidate thesefindings and hopefully clarify which changes in lipid metabolism are most relevant in AD pathogenesis. It is hoped this will pave the way towards effective treatments, whilst highlighting the importance of preventing dyslipidaemia.
AB - Lipidomics and genomics studies have made it very clear that lipids and theirmetabolism are central in AD pathogenesis. This review has described many of the lipid-related changes that occur in AD, demonstrating the wide range of such changes and, in some cases, listing potential therapeutic treatments. Reducing the risk of AD will involve dietary changes and healthy lifestyles that can reduce the risk of dyslipidaemia, insulin resistance, type 2 diabetes, cardiovascular disease, and chronic inflammation, which are all known risk factors for AD. Despite the many studies on the influence of the APOE 휀4 allele on Aβ aggregation, binding, and clearance, the overall pathological effect of this allele is still not known. Further studies will consolidate thesefindings and hopefully clarify which changes in lipid metabolism are most relevant in AD pathogenesis. It is hoped this will pave the way towards effective treatments, whilst highlighting the importance of preventing dyslipidaemia.
M3 - Chapter
SN - 9781119356783
SP - 189
EP - 231
BT - Neurodegeneration and Alzheimer's Disease
PB - John Wiley & Sons
CY - London
ER -