Family history of cancer and the risk of childhood brain tumors: a pooled analysis of the ESCALE and ESTELLE studies (SFCE)

Nicolas Vidart d’Egurbide Bagazgoïtia, Helen D. Bailey, Laurent Orsi, Léa Guerrini-Rousseau, Anne Isabelle Bertozzi, Cécile Faure-Conter, Pierre Leblond, Isabelle Pellier, Claire Freycon, François Doz, Stéphanie Puget, Stéphane Ducassou, Brigitte Lacour, Jacqueline Clavel

Research output: Contribution to journalArticle


Purpose: Although some specific genetic syndromes such as neurofibromatosis (NF) have been identified as risk factor of childhood brain tumors (CBT), the potential role of inherited susceptibility in CBT has yet to be elucidated. Methods: To further investigate this, we conducted a pooled analysis of two nationwide case–control studies ESCALE and ESTELLE. The mothers of 509 CBT cases and 3,102 controls aged under 15 years who resided in France at diagnosis/interview, frequency-matched by age and gender, responded to a telephone interview conducted by trained interviewers. Pooled odds ratio (OR) and 95% confidence intervals (95% CI) were estimated using unconditional logistic regression. Results: CBT was significantly associated with the family history of cancer in relatives (OR 1.2, 95% CI 1.0–1.5). The OR was slightly higher for maternal relatives than for paternal relatives, and when at least two relatives had a history of cancer. CBT was significantly associated with a family history of brain tumor (OR 2.1, 95% CI 1.3–3.7). This association seemed stronger for first-degree relatives (mother, father, and siblings), for whom, by contrast, no association was seen for cancers other than CBT. No specificity by CBT subtypes or by age of the children were found for any of these findings. Conclusion: Our findings support the hypothesis of a familial susceptibility of CBT, not due to being a known NF carrier.

Original languageEnglish
Pages (from-to)1075-1085
Number of pages11
JournalCancer Causes and Control
Issue number10
Publication statusPublished - 1 Oct 2019

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