TY - JOUR
T1 - Familial inclusion body myositis in a mother and son with different ancestral MHC haplotypes
AU - Mastaglia, Francis
AU - Price, Patricia
AU - Walters, S.
AU - Fabian, V.
AU - Miller, J.
AU - Zilko, P.J.
PY - 2006
Y1 - 2006
N2 - An Ashkenazi Jewish family in which the mother and a son both have inclusion body myositis (IBM) is reported. The condition developed at an earlier age and was more rapidly progressive and less responsive to treatment in the son than in the mother or other IBM patients in our clinic. Genetic analysis showed that the mother carried alleles of the 8.1 MHC ancestral haplotype (AH; HLA-B8, DRB1*0301), which is found in 85% of IBM patients in Western Australia. The son did not inherit this haplotype, but carried alleles characteristic of the 52.1AH (HLA-B5, DRB1*1502) of paternal origin. The findings indicate that in this family either the 8.1 AH or 52.1AH may carry susceptibility for IBM and that the 52.1AH is associated with a more severe and treatment-resistant form of the disease. (C) 2006 Elsevier B.V. All rights reserved.
AB - An Ashkenazi Jewish family in which the mother and a son both have inclusion body myositis (IBM) is reported. The condition developed at an earlier age and was more rapidly progressive and less responsive to treatment in the son than in the mother or other IBM patients in our clinic. Genetic analysis showed that the mother carried alleles of the 8.1 MHC ancestral haplotype (AH; HLA-B8, DRB1*0301), which is found in 85% of IBM patients in Western Australia. The son did not inherit this haplotype, but carried alleles characteristic of the 52.1AH (HLA-B5, DRB1*1502) of paternal origin. The findings indicate that in this family either the 8.1 AH or 52.1AH may carry susceptibility for IBM and that the 52.1AH is associated with a more severe and treatment-resistant form of the disease. (C) 2006 Elsevier B.V. All rights reserved.
U2 - 10.1016/j.nmd.2006.06.009
DO - 10.1016/j.nmd.2006.06.009
M3 - Article
C2 - 16934978
SN - 0960-8966
VL - 16
SP - 754
EP - 758
JO - Neuromuscular Disorders
JF - Neuromuscular Disorders
ER -