Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: Guidance for clinicians to prevent coronary heart disease

B.G. Nørdestgaard; M.J. Chapman; S.E. Humphries; H.N. Ginsberg; L.L. Masana; O.S. Descamps; O. Wiklund; R.A. Hegele; F.J. Raal; J.C. Defesche; A. Wiegman; R.D.D. Santos; Gerald Watts; K.G. Parhofer; G.K. Hovingh; P.T. Kovanen; C.R. Boileau; M.R. Averna; J. Borén; E. Bruckert; A.L. Catapano; J.A. Kuivenhoven; P.E. Pajukanta; K.K. Ray; A.F.H. Stalenhoef; E.S.G. Stroes; M.R. Taskinen; A. Tybjærg-Hansen

doi:10.1093/eurheartj/eht273

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: Guidance for clinicians to prevent coronary heart disease

B.G. Nørdestgaard, M.J. Chapman, S.E. Humphries, H.N. Ginsberg, L.L. Masana, O.S. Descamps, O. Wiklund, R.A. Hegele, F.J. Raal, J.C. Defesche, A. Wiegman, R.D.D. Santos, Gerald Watts, K.G. Parhofer, G.K. Hovingh, P.T. Kovanen, C.R. Boileau, M.R. Averna, J. Borén, E. BruckertA.L. Catapano, J.A. Kuivenhoven, P.E. Pajukanta, K.K. Ray, A.F.H. Stalenhoef, E.S.G. Stroes, M.R. Taskinen, A. Tybjærg-Hansen

Graduate Research School

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Abstract

Aims The first aim was to critically evaluate the extent to which familial hypercholesterolaemia (FH) is underdiagnosed and undertreated. The second aim was to provide guidance for screening and treatment of FH, in order to prevent coronary heart disease (CHD). Methods and results Of the theoretical estimated prevalence of 1/500 for heterozygous FH,

Original language	English
Pages (from-to)	3478-3490a
Journal	European Heart Journal
Volume	34
Issue number	45
DOIs	https://doi.org/10.1093/eurheartj/eht273
Publication status	Published - 2013

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Nørdestgaard, B. G., Chapman, M. J., Humphries, S. E., Ginsberg, H. N., Masana, L. L., Descamps, O. S., Wiklund, O., Hegele, R. A., Raal, F. J., Defesche, J. C., Wiegman, A., Santos, R. D. D., Watts, G., Parhofer, K. G., Hovingh, G. K., Kovanen, P. T., Boileau, C. R., Averna, M. R., Borén, J., ... Tybjærg-Hansen, A. (2013). Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: Guidance for clinicians to prevent coronary heart disease. European Heart Journal, 34(45), 3478-3490a. https://doi.org/10.1093/eurheartj/eht273

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title = "Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: Guidance for clinicians to prevent coronary heart disease",

abstract = "Aims The first aim was to critically evaluate the extent to which familial hypercholesterolaemia (FH) is underdiagnosed and undertreated. The second aim was to provide guidance for screening and treatment of FH, in order to prevent coronary heart disease (CHD). Methods and results Of the theoretical estimated prevalence of 1/500 for heterozygous FH,",

author = "B.G. N{\o}rdestgaard and M.J. Chapman and S.E. Humphries and H.N. Ginsberg and L.L. Masana and O.S. Descamps and O. Wiklund and R.A. Hegele and F.J. Raal and J.C. Defesche and A. Wiegman and R.D.D. Santos and Gerald Watts and K.G. Parhofer and G.K. Hovingh and P.T. Kovanen and C.R. Boileau and M.R. Averna and J. Bor{\'e}n and E. Bruckert and A.L. Catapano and J.A. Kuivenhoven and P.E. Pajukanta and K.K. Ray and A.F.H. Stalenhoef and E.S.G. Stroes and M.R. Taskinen and A. Tybj{\ae}rg-Hansen",

year = "2013",

doi = "10.1093/eurheartj/eht273",

language = "English",

volume = "34",

pages = "3478--3490a",

journal = "European Heart Journal",

issn = "0195-668X",

publisher = "Oxford University Press",

number = "45",

}

Nørdestgaard, BG, Chapman, MJ, Humphries, SE, Ginsberg, HN, Masana, LL, Descamps, OS, Wiklund, O, Hegele, RA, Raal, FJ, Defesche, JC, Wiegman, A, Santos, RDD, Watts, G, Parhofer, KG, Hovingh, GK, Kovanen, PT, Boileau, CR, Averna, MR, Borén, J, Bruckert, E, Catapano, AL, Kuivenhoven, JA, Pajukanta, PE, Ray, KK, Stalenhoef, AFH, Stroes, ESG, Taskinen, MR & Tybjærg-Hansen, A 2013, 'Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: Guidance for clinicians to prevent coronary heart disease', European Heart Journal, vol. 34, no. 45, pp. 3478-3490a. https://doi.org/10.1093/eurheartj/eht273

TY - JOUR

T1 - Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: Guidance for clinicians to prevent coronary heart disease

AU - Nørdestgaard, B.G.

AU - Chapman, M.J.

AU - Humphries, S.E.

AU - Ginsberg, H.N.

AU - Masana, L.L.

AU - Descamps, O.S.

AU - Wiklund, O.

AU - Hegele, R.A.

AU - Raal, F.J.

AU - Defesche, J.C.

AU - Wiegman, A.

AU - Santos, R.D.D.

AU - Watts, Gerald

AU - Parhofer, K.G.

AU - Hovingh, G.K.

AU - Kovanen, P.T.

AU - Boileau, C.R.

AU - Averna, M.R.

AU - Borén, J.

AU - Bruckert, E.

AU - Catapano, A.L.

AU - Kuivenhoven, J.A.

AU - Pajukanta, P.E.

AU - Ray, K.K.

AU - Stalenhoef, A.F.H.

AU - Stroes, E.S.G.

AU - Taskinen, M.R.

AU - Tybjærg-Hansen, A.

PY - 2013

Y1 - 2013

N2 - Aims The first aim was to critically evaluate the extent to which familial hypercholesterolaemia (FH) is underdiagnosed and undertreated. The second aim was to provide guidance for screening and treatment of FH, in order to prevent coronary heart disease (CHD). Methods and results Of the theoretical estimated prevalence of 1/500 for heterozygous FH,

AB - Aims The first aim was to critically evaluate the extent to which familial hypercholesterolaemia (FH) is underdiagnosed and undertreated. The second aim was to provide guidance for screening and treatment of FH, in order to prevent coronary heart disease (CHD). Methods and results Of the theoretical estimated prevalence of 1/500 for heterozygous FH,

U2 - 10.1093/eurheartj/eht273

DO - 10.1093/eurheartj/eht273

M3 - Article

C2 - 23956253

SN - 0195-668X

VL - 34

SP - 3478-3490a

JO - European Heart Journal

JF - European Heart Journal

IS - 45

ER -

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: Guidance for clinicians to prevent coronary heart disease

Abstract

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