Familial and non-familial risk factors associated with incidence of colorectal cancer in young and middle-aged persons in Western Australia

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Abstract

Aims: The aim of this study was to examine factors including family history, medical history and comorbidities associated with the risk of colorectal cancer (CRC) in young (18–49 years) and middle-age (50–69 years) individuals. Methods: State records were used to identify individuals born in Western Australia between 1945 and 1996, and their first-degree relatives. Individuals in the cohort and their relatives were linked to State cancer registry, hospital and mortality data to identify diagnoses of CRC and other risk factors. The associations between CRC and identified risk factors were examined using multivariable logistic regression. Results: For both young and middle-aged patients, family history of CRC, and a history of smoking, inflammatory bowel disease, liver disease and non-CRC cancer were associated with a significant increase in odds of CRC. In middle-aged patients, having a colonoscopy in the previous 10 years was associated with a reduced odds of CRC regardless of the detection of polyps. However, in young patients only the absence of polyps as confirmed by colonoscopy was associated with a decreased risk of CRC (OR: 0.38, 95%CI: 0.26 – 0.54, p < 0.001). Conclusions: Many of the risk factors associated with CRC were similar in young and middle-aged persons, and should be used to identify high risk young patients for screening. The association between colonoscopy and polyps with CRC was modified by age, likely as the result of routine screening in middle-aged patients.

Original languageEnglish
Article number101591
JournalCancer Epidemiology
Volume62
DOIs
Publication statusPublished - 1 Oct 2019

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Western Australia
Colorectal Neoplasms
Incidence
Colonoscopy
Polyps
Medical History Taking
Cancer Care Facilities
Liver Neoplasms
Hospital Mortality
Inflammatory Bowel Diseases
Registries
Comorbidity
Liver Diseases
Logistic Models
Smoking

Cite this

@article{d3eab2aea24f4d379de9ff85714b954e,
title = "Familial and non-familial risk factors associated with incidence of colorectal cancer in young and middle-aged persons in Western Australia",
abstract = "Aims: The aim of this study was to examine factors including family history, medical history and comorbidities associated with the risk of colorectal cancer (CRC) in young (18–49 years) and middle-age (50–69 years) individuals. Methods: State records were used to identify individuals born in Western Australia between 1945 and 1996, and their first-degree relatives. Individuals in the cohort and their relatives were linked to State cancer registry, hospital and mortality data to identify diagnoses of CRC and other risk factors. The associations between CRC and identified risk factors were examined using multivariable logistic regression. Results: For both young and middle-aged patients, family history of CRC, and a history of smoking, inflammatory bowel disease, liver disease and non-CRC cancer were associated with a significant increase in odds of CRC. In middle-aged patients, having a colonoscopy in the previous 10 years was associated with a reduced odds of CRC regardless of the detection of polyps. However, in young patients only the absence of polyps as confirmed by colonoscopy was associated with a decreased risk of CRC (OR: 0.38, 95{\%}CI: 0.26 – 0.54, p < 0.001). Conclusions: Many of the risk factors associated with CRC were similar in young and middle-aged persons, and should be used to identify high risk young patients for screening. The association between colonoscopy and polyps with CRC was modified by age, likely as the result of routine screening in middle-aged patients.",
keywords = "Colorectal cancer, Family history, Middle-aged, Risk factors, Young",
author = "Erin Kelty and Ward, {Sarah V.} and Gemma Cadby and McCarthy, {Nina S.} and Peter O'Leary and Moses, {Eric K.} and Ee, {Hooi C.} and Preen, {David B.}",
year = "2019",
month = "10",
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doi = "10.1016/j.canep.2019.101591",
language = "English",
volume = "62",
journal = "Cancer Detection and Prevention",
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TY - JOUR

T1 - Familial and non-familial risk factors associated with incidence of colorectal cancer in young and middle-aged persons in Western Australia

AU - Kelty, Erin

AU - Ward, Sarah V.

AU - Cadby, Gemma

AU - McCarthy, Nina S.

AU - O'Leary, Peter

AU - Moses, Eric K.

AU - Ee, Hooi C.

AU - Preen, David B.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Aims: The aim of this study was to examine factors including family history, medical history and comorbidities associated with the risk of colorectal cancer (CRC) in young (18–49 years) and middle-age (50–69 years) individuals. Methods: State records were used to identify individuals born in Western Australia between 1945 and 1996, and their first-degree relatives. Individuals in the cohort and their relatives were linked to State cancer registry, hospital and mortality data to identify diagnoses of CRC and other risk factors. The associations between CRC and identified risk factors were examined using multivariable logistic regression. Results: For both young and middle-aged patients, family history of CRC, and a history of smoking, inflammatory bowel disease, liver disease and non-CRC cancer were associated with a significant increase in odds of CRC. In middle-aged patients, having a colonoscopy in the previous 10 years was associated with a reduced odds of CRC regardless of the detection of polyps. However, in young patients only the absence of polyps as confirmed by colonoscopy was associated with a decreased risk of CRC (OR: 0.38, 95%CI: 0.26 – 0.54, p < 0.001). Conclusions: Many of the risk factors associated with CRC were similar in young and middle-aged persons, and should be used to identify high risk young patients for screening. The association between colonoscopy and polyps with CRC was modified by age, likely as the result of routine screening in middle-aged patients.

AB - Aims: The aim of this study was to examine factors including family history, medical history and comorbidities associated with the risk of colorectal cancer (CRC) in young (18–49 years) and middle-age (50–69 years) individuals. Methods: State records were used to identify individuals born in Western Australia between 1945 and 1996, and their first-degree relatives. Individuals in the cohort and their relatives were linked to State cancer registry, hospital and mortality data to identify diagnoses of CRC and other risk factors. The associations between CRC and identified risk factors were examined using multivariable logistic regression. Results: For both young and middle-aged patients, family history of CRC, and a history of smoking, inflammatory bowel disease, liver disease and non-CRC cancer were associated with a significant increase in odds of CRC. In middle-aged patients, having a colonoscopy in the previous 10 years was associated with a reduced odds of CRC regardless of the detection of polyps. However, in young patients only the absence of polyps as confirmed by colonoscopy was associated with a decreased risk of CRC (OR: 0.38, 95%CI: 0.26 – 0.54, p < 0.001). Conclusions: Many of the risk factors associated with CRC were similar in young and middle-aged persons, and should be used to identify high risk young patients for screening. The association between colonoscopy and polyps with CRC was modified by age, likely as the result of routine screening in middle-aged patients.

KW - Colorectal cancer

KW - Family history

KW - Middle-aged

KW - Risk factors

KW - Young

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