FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on Health

Berthold Koletzko, Eva Reischl, Conny Tanjung, Ines Gonzalez-Casanova, Usha Ramakrishnan, Suzanne Meldrum, Karen Simmer, Joachim Heinrich, Hans Demmelmair

Research output: Contribution to journalArticle

Abstract

Variants in the FADS gene cluster modify the activity of polyunsaturated fatty acid (PUFA) desaturation and the lipid composition in human blood and tissue. FADS variants have been associated with plasma lipid concentrations, risk of cardiovascular diseases, overweight, eczema, pregnancy outcomes, and cognitive function. Studies on variations in the FADS genecluster provided some of the first examples for marked gene-diet interactions in modulating complex phenotypes, such as eczema, asthma, and cognition. Genotype distribution differs markedly among ethnicities, apparently reflecting an evolutionary advantage of genotypes enabling active long-chain PUFA synthesis when the introduction of agriculture provided diets rich in linoleic acid but with little arachidonic and eicosapentaenoic acids. Discovering differential effects of PUFA supply that depend on variation of FADS genotypes could open new opportunities for developing precision nutrition strategies based either on an individual's genotype or on genotype distributions in specific populations.

Original languageEnglish
Pages (from-to)21-44
Number of pages24
JournalAnnual Review of Nutrition
Volume39
DOIs
Publication statusPublished - 21 Aug 2019

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Fatty Acids
Genotype
Unsaturated Fatty Acids
Health
Eczema
Cognition
Arachidonic Acids
Diet
Lipids
Linoleic Acid
Pregnancy Outcome
Multigene Family
Agriculture
Cardiovascular Diseases
Asthma
Phenotype
Population
Genes

Cite this

Koletzko, B., Reischl, E., Tanjung, C., Gonzalez-Casanova, I., Ramakrishnan, U., Meldrum, S., ... Demmelmair, H. (2019). FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on Health. Annual Review of Nutrition, 39, 21-44. https://doi.org/10.1146/annurev-nutr-082018-124250
Koletzko, Berthold ; Reischl, Eva ; Tanjung, Conny ; Gonzalez-Casanova, Ines ; Ramakrishnan, Usha ; Meldrum, Suzanne ; Simmer, Karen ; Heinrich, Joachim ; Demmelmair, Hans. / FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on Health. In: Annual Review of Nutrition. 2019 ; Vol. 39. pp. 21-44.
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Koletzko, B, Reischl, E, Tanjung, C, Gonzalez-Casanova, I, Ramakrishnan, U, Meldrum, S, Simmer, K, Heinrich, J & Demmelmair, H 2019, 'FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on Health' Annual Review of Nutrition, vol. 39, pp. 21-44. https://doi.org/10.1146/annurev-nutr-082018-124250

FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on Health. / Koletzko, Berthold; Reischl, Eva; Tanjung, Conny; Gonzalez-Casanova, Ines; Ramakrishnan, Usha; Meldrum, Suzanne; Simmer, Karen; Heinrich, Joachim; Demmelmair, Hans.

In: Annual Review of Nutrition, Vol. 39, 21.08.2019, p. 21-44.

Research output: Contribution to journalArticle

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AU - Gonzalez-Casanova, Ines

AU - Ramakrishnan, Usha

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AU - Heinrich, Joachim

AU - Demmelmair, Hans

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Koletzko B, Reischl E, Tanjung C, Gonzalez-Casanova I, Ramakrishnan U, Meldrum S et al. FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on Health. Annual Review of Nutrition. 2019 Aug 21;39:21-44. https://doi.org/10.1146/annurev-nutr-082018-124250