Factors related to pregnancy and birth and the risk of childhood brain tumours: The ESTELLE and ESCALE studies (SFCE, France)

Helen D Bailey, Paula Rios, Brigitte Lacour, Léa Guerrini-Rousseau, Anne-Isabelle Bertozzi, Pierre Leblond, Cécile Faure-Conter, Isabelle Pellier, Claire Freycon, Jean Michon, Stéphanie Puget, Stéphane Ducassou, Laurent Orsi, Jacqueline Clavel

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Little is known of the causes of childhood brain tumors (CBT). The aims of this study were to investigate whether extremes of birth weight were associated with increased risk of CBT and whether maternal preconceptional folic acid supplementation or breastfeeding reduced the risk. In addition, other maternal characteristics and birth related factors were also investigated. We pooled data from two French national population-based case-control studies with similar designs conducted in 2003-2004 and 2010-2011. The mothers of 510 CBT cases (directly recruited from the national childhood cancer register) and 3,102 controls aged under 15 years, frequency matched by age and gender did a telephone interview, which focussed on demographic and perinatal characteristics, and maternal life style habits and reproductive history. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression, adjusted for age, sex, study of origin and relevant confounders. No association was found between CBT and birth weight or fetal growth. The use of preconceptional folic acid supplementation was rare (5.3% in cases and 7.8% in controls) and the OR was 0.8 (95% CI 0.5, 1.4). There was no association with breastfeeding, even prolonged (six months or more; OR 1.0, 95% CI 0.8, 1.4). Neither was there any association between CBT and other investigated factors (maternal body mass index, gestational weight gain, congenital abnormality, maternal reproductive history or use of fertility treatments. Although large, this study was underpowered for subtype analyses. Pooling data with other population-based studies may provide further insight into findings by CBT subtypes.

Original languageEnglish
Pages (from-to)1757-1769
Number of pages13
JournalInternational Journal of Cancer
Volume140
Issue number8
DOIs
Publication statusPublished - 15 Apr 2017
Externally publishedYes

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Brain Neoplasms
France
Mothers
Parturition
Pregnancy
Reproductive History
Odds Ratio
Confidence Intervals
Breast Feeding
Folic Acid
Birth Weight
Fetal Development
Tumor Burden
Population
Weight Gain
Habits
Fertility
Meta-Analysis
Case-Control Studies
Life Style

Cite this

Bailey, Helen D ; Rios, Paula ; Lacour, Brigitte ; Guerrini-Rousseau, Léa ; Bertozzi, Anne-Isabelle ; Leblond, Pierre ; Faure-Conter, Cécile ; Pellier, Isabelle ; Freycon, Claire ; Michon, Jean ; Puget, Stéphanie ; Ducassou, Stéphane ; Orsi, Laurent ; Clavel, Jacqueline. / Factors related to pregnancy and birth and the risk of childhood brain tumours : The ESTELLE and ESCALE studies (SFCE, France). In: International Journal of Cancer. 2017 ; Vol. 140, No. 8. pp. 1757-1769.
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abstract = "Little is known of the causes of childhood brain tumors (CBT). The aims of this study were to investigate whether extremes of birth weight were associated with increased risk of CBT and whether maternal preconceptional folic acid supplementation or breastfeeding reduced the risk. In addition, other maternal characteristics and birth related factors were also investigated. We pooled data from two French national population-based case-control studies with similar designs conducted in 2003-2004 and 2010-2011. The mothers of 510 CBT cases (directly recruited from the national childhood cancer register) and 3,102 controls aged under 15 years, frequency matched by age and gender did a telephone interview, which focussed on demographic and perinatal characteristics, and maternal life style habits and reproductive history. Odds ratios (OR) and 95{\%} confidence intervals (CI) were estimated using unconditional logistic regression, adjusted for age, sex, study of origin and relevant confounders. No association was found between CBT and birth weight or fetal growth. The use of preconceptional folic acid supplementation was rare (5.3{\%} in cases and 7.8{\%} in controls) and the OR was 0.8 (95{\%} CI 0.5, 1.4). There was no association with breastfeeding, even prolonged (six months or more; OR 1.0, 95{\%} CI 0.8, 1.4). Neither was there any association between CBT and other investigated factors (maternal body mass index, gestational weight gain, congenital abnormality, maternal reproductive history or use of fertility treatments. Although large, this study was underpowered for subtype analyses. Pooling data with other population-based studies may provide further insight into findings by CBT subtypes.",
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Bailey, HD, Rios, P, Lacour, B, Guerrini-Rousseau, L, Bertozzi, A-I, Leblond, P, Faure-Conter, C, Pellier, I, Freycon, C, Michon, J, Puget, S, Ducassou, S, Orsi, L & Clavel, J 2017, 'Factors related to pregnancy and birth and the risk of childhood brain tumours: The ESTELLE and ESCALE studies (SFCE, France)' International Journal of Cancer, vol. 140, no. 8, pp. 1757-1769. https://doi.org/10.1002/ijc.30597

Factors related to pregnancy and birth and the risk of childhood brain tumours : The ESTELLE and ESCALE studies (SFCE, France). / Bailey, Helen D; Rios, Paula; Lacour, Brigitte; Guerrini-Rousseau, Léa; Bertozzi, Anne-Isabelle; Leblond, Pierre; Faure-Conter, Cécile; Pellier, Isabelle; Freycon, Claire; Michon, Jean; Puget, Stéphanie; Ducassou, Stéphane; Orsi, Laurent; Clavel, Jacqueline.

In: International Journal of Cancer, Vol. 140, No. 8, 15.04.2017, p. 1757-1769.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Factors related to pregnancy and birth and the risk of childhood brain tumours

T2 - The ESTELLE and ESCALE studies (SFCE, France)

AU - Bailey, Helen D

AU - Rios, Paula

AU - Lacour, Brigitte

AU - Guerrini-Rousseau, Léa

AU - Bertozzi, Anne-Isabelle

AU - Leblond, Pierre

AU - Faure-Conter, Cécile

AU - Pellier, Isabelle

AU - Freycon, Claire

AU - Michon, Jean

AU - Puget, Stéphanie

AU - Ducassou, Stéphane

AU - Orsi, Laurent

AU - Clavel, Jacqueline

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N2 - Little is known of the causes of childhood brain tumors (CBT). The aims of this study were to investigate whether extremes of birth weight were associated with increased risk of CBT and whether maternal preconceptional folic acid supplementation or breastfeeding reduced the risk. In addition, other maternal characteristics and birth related factors were also investigated. We pooled data from two French national population-based case-control studies with similar designs conducted in 2003-2004 and 2010-2011. The mothers of 510 CBT cases (directly recruited from the national childhood cancer register) and 3,102 controls aged under 15 years, frequency matched by age and gender did a telephone interview, which focussed on demographic and perinatal characteristics, and maternal life style habits and reproductive history. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression, adjusted for age, sex, study of origin and relevant confounders. No association was found between CBT and birth weight or fetal growth. The use of preconceptional folic acid supplementation was rare (5.3% in cases and 7.8% in controls) and the OR was 0.8 (95% CI 0.5, 1.4). There was no association with breastfeeding, even prolonged (six months or more; OR 1.0, 95% CI 0.8, 1.4). Neither was there any association between CBT and other investigated factors (maternal body mass index, gestational weight gain, congenital abnormality, maternal reproductive history or use of fertility treatments. Although large, this study was underpowered for subtype analyses. Pooling data with other population-based studies may provide further insight into findings by CBT subtypes.

AB - Little is known of the causes of childhood brain tumors (CBT). The aims of this study were to investigate whether extremes of birth weight were associated with increased risk of CBT and whether maternal preconceptional folic acid supplementation or breastfeeding reduced the risk. In addition, other maternal characteristics and birth related factors were also investigated. We pooled data from two French national population-based case-control studies with similar designs conducted in 2003-2004 and 2010-2011. The mothers of 510 CBT cases (directly recruited from the national childhood cancer register) and 3,102 controls aged under 15 years, frequency matched by age and gender did a telephone interview, which focussed on demographic and perinatal characteristics, and maternal life style habits and reproductive history. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression, adjusted for age, sex, study of origin and relevant confounders. No association was found between CBT and birth weight or fetal growth. The use of preconceptional folic acid supplementation was rare (5.3% in cases and 7.8% in controls) and the OR was 0.8 (95% CI 0.5, 1.4). There was no association with breastfeeding, even prolonged (six months or more; OR 1.0, 95% CI 0.8, 1.4). Neither was there any association between CBT and other investigated factors (maternal body mass index, gestational weight gain, congenital abnormality, maternal reproductive history or use of fertility treatments. Although large, this study was underpowered for subtype analyses. Pooling data with other population-based studies may provide further insight into findings by CBT subtypes.

KW - Adolescent

KW - Adult

KW - Birth Weight

KW - Body Mass Index

KW - Brain Neoplasms/diagnosis

KW - Breast Feeding

KW - Case-Control Studies

KW - Child

KW - Female

KW - France

KW - Humans

KW - Logistic Models

KW - Male

KW - Mothers

KW - Pregnancy

KW - Risk Factors

U2 - 10.1002/ijc.30597

DO - 10.1002/ijc.30597

M3 - Article

VL - 140

SP - 1757

EP - 1769

JO - International Journal of Cancer (Predictive Oncology)

JF - International Journal of Cancer (Predictive Oncology)

SN - 0020-7136

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ER -