Factors influencing the growth competition between Naegleria species and biofilm colonisation

Haylea Miller

Research output: ThesisDoctoral Thesis

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Abstract

Naegleria fowleri causes amoebic meningoencephalitis and is an emerging pathogen associated with drinking water distribution systems (DWDSs). The presence of pipe wall biofilm increased N. fowleri resistance to chlorine disinfection. Amoebae had preferred bacterial prey, with unusual biofilm co-colonisation by Vermamoeba sp. and N. fowleri, probably related to prey differences. A rapid metabolomics detection technique was developed to improve N. fowleri monitoring, and intracellular bacteria found in N. fowleri may also be a useful biomarker for detecting this pathogen. The results of the study will improve monitoring and prediction of N. fowleri colonisation of DWDSs.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Puzon, Geoffrey J., Supervisor, External person
  • Kaksonen, Anna, Supervisor
  • Sutton, David, Supervisor
Award date14 Sep 2017
DOIs
Publication statusUnpublished - 2017

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