TY - JOUR
T1 - Factor VIII manufactured from plasma - the ups and downs, and the up again: a personal journey
T2 - part 2: aspects of factor VIII manufacture from plasma
AU - Farrugia, Albert
PY - 2018
Y1 - 2018
N2 - Despite the advances in the manufacture of plasma derived FVIII (pd-FVIII), there has been practically no improvement in the yield of biological activity over the past 20 years, with 80% of the activity in the donated plasma being lost over the process. In this review, I look back on the decades of scientific progression of pd-FVIII development, including 40 years of personal involvement, with the intention of proposing routes to improved understanding and manufacture
AB - Despite the advances in the manufacture of plasma derived FVIII (pd-FVIII), there has been practically no improvement in the yield of biological activity over the past 20 years, with 80% of the activity in the donated plasma being lost over the process. In this review, I look back on the decades of scientific progression of pd-FVIII development, including 40 years of personal involvement, with the intention of proposing routes to improved understanding and manufacture
UR - http://aob.amegroups.com/about/editorialPolicies#openAccessPolicy
U2 - 10.21037/aob.2018.02.05
DO - 10.21037/aob.2018.02.05
M3 - Review article
SN - 2521-361X
VL - 3
SP - 1
EP - 10
JO - Annals of Blood
JF - Annals of Blood
IS - 20
ER -