Extracting something from nothing: In vivo imaging of human cutaneous lymphatic vessels using optical coherence tomography

Peijun Gong; Shaghayegh Es'Haghian; Karl Anton Harms; Alexandra Murray; Suzanne Rea; Fiona M. Wood; David D. Sampson; Robert A. McLaughlin

doi:10.1109/IPCon.2016.7831014

Extracting something from nothing: In vivo imaging of human cutaneous lymphatic vessels using optical coherence tomography

Peijun Gong, Shaghayegh Es'Haghian, Karl Anton Harms, Alexandra Murray, Suzanne Rea, Fiona M. Wood, David D. Sampson, Robert A. McLaughlin

School of Engineering

Research output: Chapter in Book/Conference paper › Conference paper › peer-review

Abstract

We propose a method to image cutaneous lymphatic vessels in vivo with optical coherence tomography (OCT). Our method segments the transparent lymphatic vessels by thresholding the OCT signal after calibration for systematic variations due to the confocal effect and the sensitivity drop-off, and subsequent compensation for light attenuation with depth. We describe the method and present a pilot demonstration on two human burn scar patients undergoing ablative laser fractionation treatment. The results show visualization of the lymphatic vessels (diameter: ∼30-150 μm) separate from the blood microvasculature network.

Original language	English
Title of host publication	2016 IEEE Photonics Conference, IPC 2016
Place of Publication	USA
Publisher	IEEE, Institute of Electrical and Electronics Engineers
Pages	138-139
Number of pages	2
ISBN (Electronic)	9781509019069
DOIs	https://doi.org/10.1109/IPCon.2016.7831014
Publication status	Published - 23 Jan 2017
Event	29th IEEE Photonics Conference, IPC 2016 - Waikoloa, United States Duration: 2 Oct 2016 → 6 Oct 2016

Conference

Conference	29th IEEE Photonics Conference, IPC 2016
Country/Territory	United States
City	Waikoloa
Period	2/10/16 → 6/10/16

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10.1109/IPCon.2016.7831014

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Gong, P., Es'Haghian, S., Harms, K. A., Murray, A., Rea, S., Wood, F. M., Sampson, D. D., & McLaughlin, R. A. (2017). Extracting something from nothing: In vivo imaging of human cutaneous lymphatic vessels using optical coherence tomography. In 2016 IEEE Photonics Conference, IPC 2016 (pp. 138-139). [7831014] IEEE, Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/IPCon.2016.7831014

@inproceedings{0bb981b3f1d54fd6ac609d59a0bc2456,

title = "Extracting something from nothing: In vivo imaging of human cutaneous lymphatic vessels using optical coherence tomography",

abstract = "We propose a method to image cutaneous lymphatic vessels in vivo with optical coherence tomography (OCT). Our method segments the transparent lymphatic vessels by thresholding the OCT signal after calibration for systematic variations due to the confocal effect and the sensitivity drop-off, and subsequent compensation for light attenuation with depth. We describe the method and present a pilot demonstration on two human burn scar patients undergoing ablative laser fractionation treatment. The results show visualization of the lymphatic vessels (diameter: ∼30-150 μm) separate from the blood microvasculature network.",

keywords = "attenuation coefficient, blood vessel, burn scars, lymphatic vessel, Optical coherence tomography (OCT), speckle decorrelation",

author = "Peijun Gong and Shaghayegh Es'Haghian and Harms, {Karl Anton} and Alexandra Murray and Suzanne Rea and Wood, {Fiona M.} and Sampson, {David D.} and McLaughlin, {Robert A.}",

year = "2017",

month = jan,

day = "23",

doi = "10.1109/IPCon.2016.7831014",

language = "English",

pages = "138--139",

booktitle = "2016 IEEE Photonics Conference, IPC 2016",

publisher = "IEEE, Institute of Electrical and Electronics Engineers",

address = "United States",

note = "29th IEEE Photonics Conference, IPC 2016 ; Conference date: 02-10-2016 Through 06-10-2016",

}

Gong, P, Es'Haghian, S, Harms, KA, Murray, A, Rea, S , Wood, FM, Sampson, DD & McLaughlin, RA 2017, Extracting something from nothing: In vivo imaging of human cutaneous lymphatic vessels using optical coherence tomography. in 2016 IEEE Photonics Conference, IPC 2016., 7831014, IEEE, Institute of Electrical and Electronics Engineers, USA, pp. 138-139, 29th IEEE Photonics Conference, IPC 2016, Waikoloa, United States, 2/10/16. https://doi.org/10.1109/IPCon.2016.7831014

Extracting something from nothing : In vivo imaging of human cutaneous lymphatic vessels using optical coherence tomography. / Gong, Peijun; Es'Haghian, Shaghayegh; Harms, Karl Anton et al.

2016 IEEE Photonics Conference, IPC 2016. USA : IEEE, Institute of Electrical and Electronics Engineers, 2017. p. 138-139 7831014.

Research output: Chapter in Book/Conference paper › Conference paper › peer-review

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AU - Gong, Peijun

AU - Es'Haghian, Shaghayegh

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AU - Murray, Alexandra

AU - Rea, Suzanne

AU - Wood, Fiona M.

AU - Sampson, David D.

AU - McLaughlin, Robert A.

PY - 2017/1/23

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N2 - We propose a method to image cutaneous lymphatic vessels in vivo with optical coherence tomography (OCT). Our method segments the transparent lymphatic vessels by thresholding the OCT signal after calibration for systematic variations due to the confocal effect and the sensitivity drop-off, and subsequent compensation for light attenuation with depth. We describe the method and present a pilot demonstration on two human burn scar patients undergoing ablative laser fractionation treatment. The results show visualization of the lymphatic vessels (diameter: ∼30-150 μm) separate from the blood microvasculature network.

AB - We propose a method to image cutaneous lymphatic vessels in vivo with optical coherence tomography (OCT). Our method segments the transparent lymphatic vessels by thresholding the OCT signal after calibration for systematic variations due to the confocal effect and the sensitivity drop-off, and subsequent compensation for light attenuation with depth. We describe the method and present a pilot demonstration on two human burn scar patients undergoing ablative laser fractionation treatment. The results show visualization of the lymphatic vessels (diameter: ∼30-150 μm) separate from the blood microvasculature network.

KW - attenuation coefficient

KW - blood vessel

KW - burn scars

KW - lymphatic vessel

KW - Optical coherence tomography (OCT)

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BT - 2016 IEEE Photonics Conference, IPC 2016

PB - IEEE, Institute of Electrical and Electronics Engineers

CY - USA

Y2 - 2 October 2016 through 6 October 2016

ER -

Extracting something from nothing: In vivo imaging of human cutaneous lymphatic vessels using optical coherence tomography

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