Extracting something from nothing: In vivo imaging of human cutaneous lymphatic vessels using optical coherence tomography

Peijun Gong, Shaghayegh Es'Haghian, Karl Anton Harms, Alexandra Murray, Suzanne Rea, Fiona M. Wood, David D. Sampson, Robert A. McLaughlin

Research output: Chapter in Book/Conference paperConference paper

Abstract

We propose a method to image cutaneous lymphatic vessels in vivo with optical coherence tomography (OCT). Our method segments the transparent lymphatic vessels by thresholding the OCT signal after calibration for systematic variations due to the confocal effect and the sensitivity drop-off, and subsequent compensation for light attenuation with depth. We describe the method and present a pilot demonstration on two human burn scar patients undergoing ablative laser fractionation treatment. The results show visualization of the lymphatic vessels (diameter: ∼30-150 μm) separate from the blood microvasculature network.

Original languageEnglish
Title of host publication2016 IEEE Photonics Conference, IPC 2016
Place of PublicationUSA
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages138-139
Number of pages2
ISBN (Electronic)9781509019069
DOIs
Publication statusPublished - 23 Jan 2017
Event29th IEEE Photonics Conference, IPC 2016 - Waikoloa, United States
Duration: 2 Oct 20166 Oct 2016

Conference

Conference29th IEEE Photonics Conference, IPC 2016
CountryUnited States
CityWaikoloa
Period2/10/166/10/16

Fingerprint

Optical tomography
vessels
tomography
Imaging techniques
Fractionation
scars
Blood
Demonstrations
Visualization
Calibration
fractionation
blood
Lasers
attenuation
sensitivity
lasers
Compensation and Redress

Cite this

Gong, P., Es'Haghian, S., Harms, K. A., Murray, A., Rea, S., Wood, F. M., ... McLaughlin, R. A. (2017). Extracting something from nothing: In vivo imaging of human cutaneous lymphatic vessels using optical coherence tomography. In 2016 IEEE Photonics Conference, IPC 2016 (pp. 138-139). [7831014] USA: IEEE, Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/IPCon.2016.7831014
Gong, Peijun ; Es'Haghian, Shaghayegh ; Harms, Karl Anton ; Murray, Alexandra ; Rea, Suzanne ; Wood, Fiona M. ; Sampson, David D. ; McLaughlin, Robert A. / Extracting something from nothing : In vivo imaging of human cutaneous lymphatic vessels using optical coherence tomography. 2016 IEEE Photonics Conference, IPC 2016. USA : IEEE, Institute of Electrical and Electronics Engineers, 2017. pp. 138-139
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Gong, P, Es'Haghian, S, Harms, KA, Murray, A, Rea, S, Wood, FM, Sampson, DD & McLaughlin, RA 2017, Extracting something from nothing: In vivo imaging of human cutaneous lymphatic vessels using optical coherence tomography. in 2016 IEEE Photonics Conference, IPC 2016., 7831014, IEEE, Institute of Electrical and Electronics Engineers, USA, pp. 138-139, 29th IEEE Photonics Conference, IPC 2016, Waikoloa, United States, 2/10/16. https://doi.org/10.1109/IPCon.2016.7831014

Extracting something from nothing : In vivo imaging of human cutaneous lymphatic vessels using optical coherence tomography. / Gong, Peijun; Es'Haghian, Shaghayegh; Harms, Karl Anton; Murray, Alexandra; Rea, Suzanne; Wood, Fiona M.; Sampson, David D.; McLaughlin, Robert A.

2016 IEEE Photonics Conference, IPC 2016. USA : IEEE, Institute of Electrical and Electronics Engineers, 2017. p. 138-139 7831014.

Research output: Chapter in Book/Conference paperConference paper

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AU - McLaughlin, Robert A.

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Gong P, Es'Haghian S, Harms KA, Murray A, Rea S, Wood FM et al. Extracting something from nothing: In vivo imaging of human cutaneous lymphatic vessels using optical coherence tomography. In 2016 IEEE Photonics Conference, IPC 2016. USA: IEEE, Institute of Electrical and Electronics Engineers. 2017. p. 138-139. 7831014 https://doi.org/10.1109/IPCon.2016.7831014