TY - JOUR
T1 - Extracellular Vesicles in Head and Neck Cancer
T2 - A Potential New Trend in Diagnosis, Prognosis, and Treatment
AU - Qu, Xinyu
AU - Li, Jing-Woei
AU - Chan, Jason
AU - Meehan, Katie
PY - 2020/11/4
Y1 - 2020/11/4
N2 - Head and neck cancer (HNC) is a fatal and debilitating disease that is characterized by steady, poor survival rates despite advances in treatment. There is an urgent and unmet need to improve our understanding of what drives this insidious cancer and causes poor outcomes. Extracellular vesicles (EVs) are small vesicles that originate from tumor cells, immune cells, and other cell types and are secreted into plasma, saliva, and other bio-fluids. EVs represent dynamic, real-time changes of cells and offer an exciting opportunity to improve our understanding of HNC biology that may translate to improved clinical practice. Considering the amplified interest in EVs, we have sought to provide a contemporary review of the most recent and salient literature that is shaping the field. Herein, we discuss the functionality of EVs in HNCs and their clinical potential with regards to biomarker and therapeutic capabilities.
AB - Head and neck cancer (HNC) is a fatal and debilitating disease that is characterized by steady, poor survival rates despite advances in treatment. There is an urgent and unmet need to improve our understanding of what drives this insidious cancer and causes poor outcomes. Extracellular vesicles (EVs) are small vesicles that originate from tumor cells, immune cells, and other cell types and are secreted into plasma, saliva, and other bio-fluids. EVs represent dynamic, real-time changes of cells and offer an exciting opportunity to improve our understanding of HNC biology that may translate to improved clinical practice. Considering the amplified interest in EVs, we have sought to provide a contemporary review of the most recent and salient literature that is shaping the field. Herein, we discuss the functionality of EVs in HNCs and their clinical potential with regards to biomarker and therapeutic capabilities.
KW - Animals
KW - Biomarkers, Tumor/analysis
KW - Extracellular Vesicles/pathology
KW - Head and Neck Neoplasms/diagnosis
KW - Humans
KW - Medical Oncology/methods
KW - Practice Patterns, Physicians'/trends
KW - Prognosis
U2 - 10.3390/ijms21218260
DO - 10.3390/ijms21218260
M3 - Review article
C2 - 33158181
SN - 1422-0067
VL - 21
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 21
M1 - 8260
ER -
