Colorectal cancer (CRC) is the third most diagnosed cancer in Australia. Patients diagnosed at a later stage often develop distant metastasis, and have a low survival rate. The ability to predict CRC metastasis remains elusive. Extracellular vesicles (EVs) are cell-derived particles secreted by all cells, including tumour cells, that are involved in cell-to-cell communication. Tumour derived EVs carry specific cargos that are believed to reflect the primary tumour and certain surface proteins have been shown to direct metastases to distant sites. This study provides preliminary evidence of the value of EVs in predicting the risk of early CRC metastasis.
|Award date||26 Apr 2022|
|Publication status||Unpublished - 2021|