Extracellular vesicles and their role in hypertension, cardiovascular risk, and target organ damage

Leslie Marisol Lugo Gavidia

Research output: ThesisDoctoral Thesis

21 Downloads (Pure)

Abstract

Extracellular vesicles (EVs) are small cell vesicles that are derived from the cell membrane in response to different biological processes. There is growing evidence supporting the association between EVs and cardiovascular disease. In this project, we standardized and validated a method to evaluate EVs using the AttuneTM Nxt Acoustic Focusing Flow Cytometer system (ThermoFisherScientific) and evaluate the EVs performance across the blood pressure spectrum. We found a relationship between EVs and high-risk phenotypes (night-time BP, organ damage, and cardiovascular risk) which demonstrate their contribution to EVs biogenesis.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Schlaich, Markus, Supervisor
  • Matthews, Vance, Supervisor
Award date9 Aug 2023
DOIs
Publication statusUnpublished - 2022

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