TY - JOUR
T1 - Extracellular Matrix in Vascular Disease, Part 2/4
T2 - JACC Focus Seminar
AU - Barallobre-Barreiro, Javier
AU - Loeys, Bart
AU - Mayr, Manuel
AU - Rienks, Marieke
AU - Verstraeten, Aline
AU - Kovacic, Jason C.
N1 - Funding Information:
Dr. Mayr is a BHF Chair Holder (CH/16/3/32406) with BHF program grant support (RG/16/14/32397). This work was supported by a joint British Heart Foundation (BHF) Project Grant (PG/17/48/32956) and a network on “Defining the Roles of Smooth Muscle Cells and other Extracellular Matrix Producing Cells in Late Stage Atherosclerotic Plaque Formation” funded by Foundation Leducq. The research was also supported by National Institute of Health Research (NIHR) Biomedical Research Centre based at Guy’s and St Thomas’ NHS (National Health Service) Foundation Trust and King’s College London in partnership with King’s College Hospital and by VASCage–Research Centre on Vascular Ageing and Stroke. As a COMET center, VASCage is funded within the COMET program-Competence Centers for Excellent Technologies by the Austrian Ministry for Climate Action, Environment, Energy, Mobility, Innovation, and Technology, the Austrian Ministry for Digital and Economic Affairs, and the federal states Tyrol, Salzburg, and Vienna. This research was also supported by funding from the University of Antwerp (Methusalem-OEC grant “Genomed” FFB190208), the Fund for Scientific Research, Flanders (FWO, Belgium, G.0356.17), The Dutch Heart Foundation (2013T093), the Marfan Foundation and the Cardiac Surgery Foundation. Dr. Barallobre-Barreiro is supported by a British Heart Foundation Intermediate Basic Science Research Fellowship (FS/19/33/34328). Dr. Loeys is senior clinical investigator of the Fund for Scientific Research, Flanders; holds a consolidator grant from the European Research Council (Genomia–ERC-COG-2017-771945); and is a member of the European Reference Network on rare vascular disorders (VASCERN). Dr. Verstraeten is a member of VASCERN. Dr. Kovacic acknowledges research support from the National Institutes of Health (R01HL130423, R01HL135093). Dr. Rienks has reported that she has no relationships relevant to the contents of this paper to disclose. Thomas Wight, MD, served as Guest Editor for this paper.
Funding Information:
Dr. Mayr is a BHF Chair Holder (CH/16/3/32406) with BHF program grant support (RG/16/14/32397). This work was supported by a joint British Heart Foundation (BHF) Project Grant (PG/17/48/32956) and a network on ?Defining the Roles of Smooth Muscle Cells and other Extracellular Matrix Producing Cells in Late Stage Atherosclerotic Plaque Formation? funded by Foundation Leducq. The research was also supported by National Institute of Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas? NHS (National Health Service) Foundation Trust and King's College London in partnership with King's College Hospital and by VASCage?Research Centre on Vascular Ageing and Stroke. As a COMET center, VASCage is funded within the COMET program-Competence Centers for Excellent Technologies by the Austrian Ministry for Climate Action, Environment, Energy, Mobility, Innovation, and Technology, the Austrian Ministry for Digital and Economic Affairs, and the federal states Tyrol, Salzburg, and Vienna. This research was also supported by funding from the University of Antwerp (Methusalem-OEC grant ?Genomed? FFB190208), the Fund for Scientific Research, Flanders (FWO, Belgium, G.0356.17), The Dutch Heart Foundation (2013T093), the Marfan Foundation and the Cardiac Surgery Foundation. Dr. Barallobre-Barreiro is supported by a British Heart Foundation Intermediate Basic Science Research Fellowship (FS/19/33/34328). Dr. Loeys is senior clinical investigator of the Fund for Scientific Research, Flanders; holds a consolidator grant from the European Research Council (Genomia?ERC-COG-2017-771945); and is a member of the European Reference Network on rare vascular disorders (VASCERN). Dr. Verstraeten is a member of VASCERN. Dr. Kovacic acknowledges research support from the National Institutes of Health (R01HL130423, R01HL135093). Dr. Rienks has reported that she has no relationships relevant to the contents of this paper to disclose. Thomas Wight, MD, served as Guest Editor for this paper.
Publisher Copyright:
© 2020 American College of Cardiology Foundation
PY - 2020/5/5
Y1 - 2020/5/5
N2 - Medium-sized and large arteries consist of 3 layers: the tunica intima, tunica media, and tunica adventitia. The tunica media accounts for the bulk of the vessel wall and is the chief determinant of mechanical compliance. It is primarily composed of circumferentially arranged layers of vascular smooth muscle cells that are separated by concentrically arranged elastic lamellae; a form of extracellular matrix (ECM). The tunica media is separated from the tunica intima and tunica adventitia, the innermost and outermost layers, respectively, by the internal and external elastic laminae. This second part of a 4-part JACC Focus Seminar discusses the contributions of the ECM to vascular homeostasis and pathology. Advances in genetics and proteomics approaches have fostered significant progress in our understanding of vascular ECM. This review highlights the important role of the ECM in vascular disease and the prospect of translating these discoveries into clinical disease biomarkers and potential future therapies.
AB - Medium-sized and large arteries consist of 3 layers: the tunica intima, tunica media, and tunica adventitia. The tunica media accounts for the bulk of the vessel wall and is the chief determinant of mechanical compliance. It is primarily composed of circumferentially arranged layers of vascular smooth muscle cells that are separated by concentrically arranged elastic lamellae; a form of extracellular matrix (ECM). The tunica media is separated from the tunica intima and tunica adventitia, the innermost and outermost layers, respectively, by the internal and external elastic laminae. This second part of a 4-part JACC Focus Seminar discusses the contributions of the ECM to vascular homeostasis and pathology. Advances in genetics and proteomics approaches have fostered significant progress in our understanding of vascular ECM. This review highlights the important role of the ECM in vascular disease and the prospect of translating these discoveries into clinical disease biomarkers and potential future therapies.
KW - aneurysm
KW - atherosclerosis
KW - extracellular matrix
KW - fibromuscular dysplasia proteomics
UR - http://www.scopus.com/inward/record.url?scp=85083506989&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2020.03.018
DO - 10.1016/j.jacc.2020.03.018
M3 - Review article
C2 - 32354385
AN - SCOPUS:85083506989
SN - 0735-1097
VL - 75
SP - 2189
EP - 2203
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 17
ER -