Extending optical coherence tomography towards intraoperative breast cancer margin assessment

Ken Foo

Research output: ThesisDoctoral Thesis

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Breast-conserving surgery is one of the main treatments for early-stage breast cancer, however, 15-25% of patients require re-excision due to cancer near the boundary of the excised tissue. One promising solution is optical coherence tomography (OCT), however, malignant tissue is sometimes challenging to differentiate from benign dense tissue. In this thesis, we investigate several OCT contrast enhancement techniques that measure optical and mechanical tissue properties, namely, attenuation imaging, strain imaging, elasticity imaging, and optical palpation. The results indicate that these contrast enhancement techniques can improve the ability of both humans and deep learning models to identify cancer in OCT images.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
  • Kennedy, Brendan, Supervisor
  • Chin, Lixin, Supervisor
Thesis sponsors
Award date4 Oct 2022
Publication statusUnpublished - 2022


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