TY - JOUR
T1 - Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression
T2 - A multicentre immunohistochemical study in the Asia-Pacific region
AU - Putti, T. C.
AU - To, K. F.
AU - Hsu, Heychi
AU - Chan, Anthonty Tak Cheung
AU - Lai, Gingming
AU - Tse, G.
AU - Lee, Yoke Sun
AU - Whang-Peng, J.
AU - Millward, M.
AU - Lin, Liching
AU - Lin, Xiao
AU - Lee, Cheok Soon
PY - 2002/8
Y1 - 2002/8
N2 - Aims: With ongoing efforts to target the epidermal growth factor receptor (EGFR)-mediated tumour growth in the treatment of selected human malignancies, there is a need to determine the expression levels of EGFR and to evaluate its prognostic value in various malignancies in the Asia-Pacific region. Methods and results: A total of 172 patients with head and neck squamous cell carcinomas from Australia, Hong Kong, Singapore, and Taiwan were selected for EGFR detection. Immunohistochemical staining was performed to evaluate EGFR expression. EGFR expression was present in 88.4% (152/172) of all cases tested. Specifically, EGFR expression was found in 91.3% (42/46), 84.6% (22/26), 84.1% (37/44), 96.0% (24/25), and 87.1% (27/31) cases of head and neck squamous cell carcinomas from the oral cavity, oropharynx, nasopharynx, hypopharynx, and larynx, respectively. The results demonstrate a stronger EGFR expression in T4 tumours (P = 0.017) and later clinical stages (P = 0.016). No significant correlation was seen with risk factors, primary tumour site and ethnicity. Conclusions: The majority of head and neck squamous cell carcinomas express EGFR, indicating the importance of studying the efficacy of anti-cancer therapy through this pathway. The results also show similar rates of receptor expression in head and neck squamous cell carcinoma patients from our region compared with other parts of the world.
AB - Aims: With ongoing efforts to target the epidermal growth factor receptor (EGFR)-mediated tumour growth in the treatment of selected human malignancies, there is a need to determine the expression levels of EGFR and to evaluate its prognostic value in various malignancies in the Asia-Pacific region. Methods and results: A total of 172 patients with head and neck squamous cell carcinomas from Australia, Hong Kong, Singapore, and Taiwan were selected for EGFR detection. Immunohistochemical staining was performed to evaluate EGFR expression. EGFR expression was present in 88.4% (152/172) of all cases tested. Specifically, EGFR expression was found in 91.3% (42/46), 84.6% (22/26), 84.1% (37/44), 96.0% (24/25), and 87.1% (27/31) cases of head and neck squamous cell carcinomas from the oral cavity, oropharynx, nasopharynx, hypopharynx, and larynx, respectively. The results demonstrate a stronger EGFR expression in T4 tumours (P = 0.017) and later clinical stages (P = 0.016). No significant correlation was seen with risk factors, primary tumour site and ethnicity. Conclusions: The majority of head and neck squamous cell carcinomas express EGFR, indicating the importance of studying the efficacy of anti-cancer therapy through this pathway. The results also show similar rates of receptor expression in head and neck squamous cell carcinoma patients from our region compared with other parts of the world.
KW - EGFR
KW - Head and neck cancer
KW - Squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=18544387934&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2559.2002.01436.x
DO - 10.1046/j.1365-2559.2002.01436.x
M3 - Article
C2 - 12147092
AN - SCOPUS:18544387934
SN - 0309-0167
VL - 41
SP - 144
EP - 151
JO - Histopathology
JF - Histopathology
IS - 2
ER -
