Exposure to pesticides and the risk of childhood brain tumors

Kathryn Greenop, Susan Peters, Helen Bailey, Lin Fritschi, J. Attia, R.J. Scott, D.C. Glass, Nicholas De Klerk, F. Alvaro, B.K. Armstrong, Elizabeth Milne

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Abstract

Purpose

Previous research has suggested positive associations between parental or childhood exposure to pesticides and risk of childhood brain tumors (CBT). This Australian case–control study of CBT investigated whether exposures to pesticides before pregnancy, during pregnancy and during childhood, were associated with an increased risk.

Methods

Cases were recruited from 10 pediatric oncology centers, and controls by random-digit dialing, frequency matched on age, sex, and State of residence. Exposure data were collected by written questionnaires and telephone interviews. Data were analyzed by unconditional logistic regression.

Results

The odds ratios (ORs) for professional pest control treatments in the home in the year before the index pregnancy, during the pregnancy, and after the child’s birth were 1.54 (95 % confidence interval (CI): 1.07, 2.22), 1.52 (95 % CI: 0.99, 2.34) and 1.04 (95 % CI: 0.75, 1.43), respectively. ORs for treatments exclusively before pregnancy and during pregnancy were 1.90 (95 % CI: 1.08, 3.36) and 1.02 (95 % CI: 0.35, 3.00), respectively. The OR for the father being home during the treatment was 1.79 (95 % CI: 0.85, 3.80). The OR for paternal occupational exposure in the year before the child’s conception was 1.36 (95 % CI: 0.66, 2.80). ORs for prenatal home pesticide exposure were elevated for low- and high-grade gliomas; effect estimates for other CBT subtypes varied and lacked precision.

Conclusions

These results suggest that preconception pesticide exposure, and possibly exposure during pregnancy, is associated with an increased CBT risk. It may be advisable for both parents to avoid pesticide exposure during this time.
Original languageEnglish
Pages (from-to)1269-1278
JournalCancer Causes & Control
Volume24
Issue number7
DOIs
Publication statusPublished - 4 May 2013

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Pesticides
Brain Neoplasms
Confidence Intervals
Pregnancy
Odds Ratio
Paternal Exposure
Pest Control
Occupational Exposure
Glioma
Fathers
Therapeutics
Parents
Logistic Models
Parturition
Interviews
Pediatrics
Research

Cite this

Greenop, Kathryn ; Peters, Susan ; Bailey, Helen ; Fritschi, Lin ; Attia, J. ; Scott, R.J. ; Glass, D.C. ; De Klerk, Nicholas ; Alvaro, F. ; Armstrong, B.K. ; Milne, Elizabeth. / Exposure to pesticides and the risk of childhood brain tumors. In: Cancer Causes & Control. 2013 ; Vol. 24, No. 7. pp. 1269-1278.
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title = "Exposure to pesticides and the risk of childhood brain tumors",
abstract = "PurposePrevious research has suggested positive associations between parental or childhood exposure to pesticides and risk of childhood brain tumors (CBT). This Australian case–control study of CBT investigated whether exposures to pesticides before pregnancy, during pregnancy and during childhood, were associated with an increased risk.MethodsCases were recruited from 10 pediatric oncology centers, and controls by random-digit dialing, frequency matched on age, sex, and State of residence. Exposure data were collected by written questionnaires and telephone interviews. Data were analyzed by unconditional logistic regression.ResultsThe odds ratios (ORs) for professional pest control treatments in the home in the year before the index pregnancy, during the pregnancy, and after the child’s birth were 1.54 (95 {\%} confidence interval (CI): 1.07, 2.22), 1.52 (95 {\%} CI: 0.99, 2.34) and 1.04 (95 {\%} CI: 0.75, 1.43), respectively. ORs for treatments exclusively before pregnancy and during pregnancy were 1.90 (95 {\%} CI: 1.08, 3.36) and 1.02 (95 {\%} CI: 0.35, 3.00), respectively. The OR for the father being home during the treatment was 1.79 (95 {\%} CI: 0.85, 3.80). The OR for paternal occupational exposure in the year before the child’s conception was 1.36 (95 {\%} CI: 0.66, 2.80). ORs for prenatal home pesticide exposure were elevated for low- and high-grade gliomas; effect estimates for other CBT subtypes varied and lacked precision.ConclusionsThese results suggest that preconception pesticide exposure, and possibly exposure during pregnancy, is associated with an increased CBT risk. It may be advisable for both parents to avoid pesticide exposure during this time.",
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Exposure to pesticides and the risk of childhood brain tumors. / Greenop, Kathryn; Peters, Susan; Bailey, Helen; Fritschi, Lin; Attia, J.; Scott, R.J.; Glass, D.C.; De Klerk, Nicholas; Alvaro, F.; Armstrong, B.K.; Milne, Elizabeth.

In: Cancer Causes & Control, Vol. 24, No. 7, 04.05.2013, p. 1269-1278.

Research output: Contribution to journalArticle

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T1 - Exposure to pesticides and the risk of childhood brain tumors

AU - Greenop, Kathryn

AU - Peters, Susan

AU - Bailey, Helen

AU - Fritschi, Lin

AU - Attia, J.

AU - Scott, R.J.

AU - Glass, D.C.

AU - De Klerk, Nicholas

AU - Alvaro, F.

AU - Armstrong, B.K.

AU - Milne, Elizabeth

PY - 2013/5/4

Y1 - 2013/5/4

N2 - PurposePrevious research has suggested positive associations between parental or childhood exposure to pesticides and risk of childhood brain tumors (CBT). This Australian case–control study of CBT investigated whether exposures to pesticides before pregnancy, during pregnancy and during childhood, were associated with an increased risk.MethodsCases were recruited from 10 pediatric oncology centers, and controls by random-digit dialing, frequency matched on age, sex, and State of residence. Exposure data were collected by written questionnaires and telephone interviews. Data were analyzed by unconditional logistic regression.ResultsThe odds ratios (ORs) for professional pest control treatments in the home in the year before the index pregnancy, during the pregnancy, and after the child’s birth were 1.54 (95 % confidence interval (CI): 1.07, 2.22), 1.52 (95 % CI: 0.99, 2.34) and 1.04 (95 % CI: 0.75, 1.43), respectively. ORs for treatments exclusively before pregnancy and during pregnancy were 1.90 (95 % CI: 1.08, 3.36) and 1.02 (95 % CI: 0.35, 3.00), respectively. The OR for the father being home during the treatment was 1.79 (95 % CI: 0.85, 3.80). The OR for paternal occupational exposure in the year before the child’s conception was 1.36 (95 % CI: 0.66, 2.80). ORs for prenatal home pesticide exposure were elevated for low- and high-grade gliomas; effect estimates for other CBT subtypes varied and lacked precision.ConclusionsThese results suggest that preconception pesticide exposure, and possibly exposure during pregnancy, is associated with an increased CBT risk. It may be advisable for both parents to avoid pesticide exposure during this time.

AB - PurposePrevious research has suggested positive associations between parental or childhood exposure to pesticides and risk of childhood brain tumors (CBT). This Australian case–control study of CBT investigated whether exposures to pesticides before pregnancy, during pregnancy and during childhood, were associated with an increased risk.MethodsCases were recruited from 10 pediatric oncology centers, and controls by random-digit dialing, frequency matched on age, sex, and State of residence. Exposure data were collected by written questionnaires and telephone interviews. Data were analyzed by unconditional logistic regression.ResultsThe odds ratios (ORs) for professional pest control treatments in the home in the year before the index pregnancy, during the pregnancy, and after the child’s birth were 1.54 (95 % confidence interval (CI): 1.07, 2.22), 1.52 (95 % CI: 0.99, 2.34) and 1.04 (95 % CI: 0.75, 1.43), respectively. ORs for treatments exclusively before pregnancy and during pregnancy were 1.90 (95 % CI: 1.08, 3.36) and 1.02 (95 % CI: 0.35, 3.00), respectively. The OR for the father being home during the treatment was 1.79 (95 % CI: 0.85, 3.80). The OR for paternal occupational exposure in the year before the child’s conception was 1.36 (95 % CI: 0.66, 2.80). ORs for prenatal home pesticide exposure were elevated for low- and high-grade gliomas; effect estimates for other CBT subtypes varied and lacked precision.ConclusionsThese results suggest that preconception pesticide exposure, and possibly exposure during pregnancy, is associated with an increased CBT risk. It may be advisable for both parents to avoid pesticide exposure during this time.

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DO - 10.1007/s10552-013-0205-1

M3 - Article

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JO - Cancer Causes & Control

JF - Cancer Causes & Control

SN - 0957-5243

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