TY - JOUR
T1 - Exploring the Phytochemicals and Anti-Cancer Potential of the Members of Fabaceae Family
T2 - A Comprehensive Review
AU - Usman, Muhammad
AU - Khan, Waseem Razzaq
AU - Yousaf, Nousheen
AU - Akram, Seemab
AU - Murtaza, Ghulam
AU - Kudus, Kamziah Abdul
AU - Ditta, Allah
AU - Rosli, Zamri
AU - Rajpar, Muhammad Nawaz
AU - Nazre, Mohd
N1 - Funding Information:
Funding: This research was funded by Universiti Putra Malaysia, Grant Number: 5540232.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Cancer is the second-ranked disease and a cause of death for millions of people around the world despite many kinds of available treatments. Phytochemicals are considered a vital source of cancer-inhibiting drugs and utilize specific mechanisms including carcinogen inactivation, the induction of cell cycle arrest, anti-oxidant stress, apoptosis, and regulation of the immune system. Family Fabaceae is the second most diverse family in the plant kingdom, and species of the family are widely distributed across the world. The species of the Fabaceae family are rich in phytochemicals (flavonoids, lectins, saponins, alkaloids, carotenoids, and phenolic acids), which exhibit a variety of health benefits, especially anti-cancer properties; therefore, exploration of the phytochemicals present in various members of this family is crucial. These phytochemicals of the Fabaceae family have not been explored in a better way yet; therefore, this review is an effort to summarize all the possible information related to the phytochemical status of the Fabaceae family and their anti-cancer properties. Moreover, various research gaps have been identified with directions for future research.
AB - Cancer is the second-ranked disease and a cause of death for millions of people around the world despite many kinds of available treatments. Phytochemicals are considered a vital source of cancer-inhibiting drugs and utilize specific mechanisms including carcinogen inactivation, the induction of cell cycle arrest, anti-oxidant stress, apoptosis, and regulation of the immune system. Family Fabaceae is the second most diverse family in the plant kingdom, and species of the family are widely distributed across the world. The species of the Fabaceae family are rich in phytochemicals (flavonoids, lectins, saponins, alkaloids, carotenoids, and phenolic acids), which exhibit a variety of health benefits, especially anti-cancer properties; therefore, exploration of the phytochemicals present in various members of this family is crucial. These phytochemicals of the Fabaceae family have not been explored in a better way yet; therefore, this review is an effort to summarize all the possible information related to the phytochemical status of the Fabaceae family and their anti-cancer properties. Moreover, various research gaps have been identified with directions for future research.
KW - anti-oxidants
KW - apoptosis
KW - cancer
KW - cancer treatment
KW - Fabaceae
KW - phytochemicals
UR - http://www.scopus.com/inward/record.url?scp=85132588455&partnerID=8YFLogxK
U2 - 10.3390/molecules27123863
DO - 10.3390/molecules27123863
M3 - Review article
C2 - 35744986
AN - SCOPUS:85132588455
SN - 1420-3049
VL - 27
JO - Molecules
JF - Molecules
IS - 12
M1 - 3863
ER -
