Exploring the molecular mechanism of karrikins and strigolactones

Adrian Scaffidi; Mark Waters; Charles S. Bond; Kingsley Dixon; Steven Smith; Emilio Ghisalberti; Gavin Flematti

doi:10.1016/j.bmcl.2012.04.016

Exploring the molecular mechanism of karrikins and strigolactones

Adrian Scaffidi, Mark Waters, Charles S. Bond, Kingsley Dixon, Steven Smith, Emilio Ghisalberti, Gavin Flematti

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

Karrikins and strigolactones are novel plant growth regulators that contain similar molecular features, but very little is known about how they elicit responses in plants. A tentative molecular mechanism has previously been proposed involving a Michael-type addition for both compounds. Through structure-activity studies with karrikins, we now propose an alternative mechanism for karrikin and strigolactone mode of action that involves hydrolysis of the butenolide ring. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	3743-3746
Journal	Bioorganic & medicinal chemistry letters
Volume	22
Issue number	11
DOIs	https://doi.org/10.1016/j.bmcl.2012.04.016
Publication status	Published - 2012

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10.1016/j.bmcl.2012.04.016

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abstract = "Karrikins and strigolactones are novel plant growth regulators that contain similar molecular features, but very little is known about how they elicit responses in plants. A tentative molecular mechanism has previously been proposed involving a Michael-type addition for both compounds. Through structure-activity studies with karrikins, we now propose an alternative mechanism for karrikin and strigolactone mode of action that involves hydrolysis of the butenolide ring. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.",

author = "Adrian Scaffidi and Mark Waters and Bond, {Charles S.} and Kingsley Dixon and Steven Smith and Emilio Ghisalberti and Gavin Flematti",

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AU - Scaffidi, Adrian

AU - Waters, Mark

AU - Bond, Charles S.

AU - Dixon, Kingsley

AU - Smith, Steven

AU - Ghisalberti, Emilio

AU - Flematti, Gavin

PY - 2012

Y1 - 2012

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AB - Karrikins and strigolactones are novel plant growth regulators that contain similar molecular features, but very little is known about how they elicit responses in plants. A tentative molecular mechanism has previously been proposed involving a Michael-type addition for both compounds. Through structure-activity studies with karrikins, we now propose an alternative mechanism for karrikin and strigolactone mode of action that involves hydrolysis of the butenolide ring. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.bmcl.2012.04.016

DO - 10.1016/j.bmcl.2012.04.016

M3 - Article

C2 - 22542018

VL - 22

SP - 3743

EP - 3746

JO - Bioorganic & medicinal chemistry letters

JF - Bioorganic & medicinal chemistry letters

SN - 0960-894X

IS - 11

ER -

Exploring the molecular mechanism of karrikins and strigolactones

Abstract

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