Exploring the molecular mechanism of karrikins and strigolactones

Adrian Scaffidi, Mark Waters, Charles S. Bond, Kingsley Dixon, Steven Smith, Emilio Ghisalberti, Gavin Flematti

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)


Karrikins and strigolactones are novel plant growth regulators that contain similar molecular features, but very little is known about how they elicit responses in plants. A tentative molecular mechanism has previously been proposed involving a Michael-type addition for both compounds. Through structure-activity studies with karrikins, we now propose an alternative mechanism for karrikin and strigolactone mode of action that involves hydrolysis of the butenolide ring. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)3743-3746
JournalBioorganic & medicinal chemistry letters
Issue number11
Publication statusPublished - 2012


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