Exploring Structural and Physical Properties of Schistosome Eggs: Potential Pathways for Novel Diagnostics

Renata Russo Frasca Candido, Alessandra Loureiro Morassutti, Carlos Graeff-Teixeira, Timothy St Pierre, Malcolm K. Jones

Research output: Chapter in Book/Conference paperChapter

2 Citations (Scopus)

Abstract

In this era of increasing demand for sensitive techniques to diagnose schistosomiasis, there is a need for an increased focus on the properties of the parasite eggs. The eggs are not only directly linked to the morbidity of chronic infection but are also potential key targets for accurate diagnostics. Eggs were the primary target of diagnostic tools in the past and we argue they could be the target of highly sensitive tools in the future if we focus on characteristics of their structure and shell surface that could be exploited for enhanced detection. In this review, we discuss the current state of knowledge of the physical structures of schistosome eggs and eggshells with a view to identifying pathways to a comprehensive understanding of their role in the host-parasite relationship and pathogenesis of infection, and pathways to new strategies for development of diagnostics.
Original languageEnglish
Title of host publicationAdvances in Parasitology
Place of PublicationUnited Kingdom
PublisherAcademic Press
Chapter6
Pages209-237
Volume100
ISBN (Print)9780128151693
DOIs
Publication statusPublished - 2018

Publication series

NameAdvances in Parasitology
PublisherAcademic Press
ISSN (Print)0065-308X

Fingerprint

Eggs
Egg Shell
Host-Parasite Interactions
Schistosomiasis
Infection
Parasites
Morbidity

Cite this

Russo Frasca Candido, R., Morassutti, A. L., Graeff-Teixeira, C., St Pierre, T., & Jones, M. K. (2018). Exploring Structural and Physical Properties of Schistosome Eggs: Potential Pathways for Novel Diagnostics. In Advances in Parasitology (Vol. 100, pp. 209-237). (Advances in Parasitology). United Kingdom: Academic Press. https://doi.org/10.1016/bs.apar.2018.03.003
Russo Frasca Candido, Renata ; Morassutti, Alessandra Loureiro ; Graeff-Teixeira, Carlos ; St Pierre, Timothy ; Jones, Malcolm K. / Exploring Structural and Physical Properties of Schistosome Eggs: Potential Pathways for Novel Diagnostics. Advances in Parasitology. Vol. 100 United Kingdom : Academic Press, 2018. pp. 209-237 (Advances in Parasitology).
@inbook{ee7917ed52bc46959a3d45951c4a8fa9,
title = "Exploring Structural and Physical Properties of Schistosome Eggs: Potential Pathways for Novel Diagnostics",
abstract = "In this era of increasing demand for sensitive techniques to diagnose schistosomiasis, there is a need for an increased focus on the properties of the parasite eggs. The eggs are not only directly linked to the morbidity of chronic infection but are also potential key targets for accurate diagnostics. Eggs were the primary target of diagnostic tools in the past and we argue they could be the target of highly sensitive tools in the future if we focus on characteristics of their structure and shell surface that could be exploited for enhanced detection. In this review, we discuss the current state of knowledge of the physical structures of schistosome eggs and eggshells with a view to identifying pathways to a comprehensive understanding of their role in the host-parasite relationship and pathogenesis of infection, and pathways to new strategies for development of diagnostics.",
author = "{Russo Frasca Candido}, Renata and Morassutti, {Alessandra Loureiro} and Carlos Graeff-Teixeira and {St Pierre}, Timothy and Jones, {Malcolm K.}",
year = "2018",
doi = "10.1016/bs.apar.2018.03.003",
language = "English",
isbn = "9780128151693",
volume = "100",
series = "Advances in Parasitology",
publisher = "Academic Press",
pages = "209--237",
booktitle = "Advances in Parasitology",
address = "United Kingdom",

}

Russo Frasca Candido, R, Morassutti, AL, Graeff-Teixeira, C, St Pierre, T & Jones, MK 2018, Exploring Structural and Physical Properties of Schistosome Eggs: Potential Pathways for Novel Diagnostics. in Advances in Parasitology. vol. 100, Advances in Parasitology, Academic Press, United Kingdom, pp. 209-237. https://doi.org/10.1016/bs.apar.2018.03.003

Exploring Structural and Physical Properties of Schistosome Eggs: Potential Pathways for Novel Diagnostics. / Russo Frasca Candido, Renata; Morassutti, Alessandra Loureiro; Graeff-Teixeira, Carlos; St Pierre, Timothy; Jones, Malcolm K.

Advances in Parasitology. Vol. 100 United Kingdom : Academic Press, 2018. p. 209-237 (Advances in Parasitology).

Research output: Chapter in Book/Conference paperChapter

TY - CHAP

T1 - Exploring Structural and Physical Properties of Schistosome Eggs: Potential Pathways for Novel Diagnostics

AU - Russo Frasca Candido, Renata

AU - Morassutti, Alessandra Loureiro

AU - Graeff-Teixeira, Carlos

AU - St Pierre, Timothy

AU - Jones, Malcolm K.

PY - 2018

Y1 - 2018

N2 - In this era of increasing demand for sensitive techniques to diagnose schistosomiasis, there is a need for an increased focus on the properties of the parasite eggs. The eggs are not only directly linked to the morbidity of chronic infection but are also potential key targets for accurate diagnostics. Eggs were the primary target of diagnostic tools in the past and we argue they could be the target of highly sensitive tools in the future if we focus on characteristics of their structure and shell surface that could be exploited for enhanced detection. In this review, we discuss the current state of knowledge of the physical structures of schistosome eggs and eggshells with a view to identifying pathways to a comprehensive understanding of their role in the host-parasite relationship and pathogenesis of infection, and pathways to new strategies for development of diagnostics.

AB - In this era of increasing demand for sensitive techniques to diagnose schistosomiasis, there is a need for an increased focus on the properties of the parasite eggs. The eggs are not only directly linked to the morbidity of chronic infection but are also potential key targets for accurate diagnostics. Eggs were the primary target of diagnostic tools in the past and we argue they could be the target of highly sensitive tools in the future if we focus on characteristics of their structure and shell surface that could be exploited for enhanced detection. In this review, we discuss the current state of knowledge of the physical structures of schistosome eggs and eggshells with a view to identifying pathways to a comprehensive understanding of their role in the host-parasite relationship and pathogenesis of infection, and pathways to new strategies for development of diagnostics.

U2 - 10.1016/bs.apar.2018.03.003

DO - 10.1016/bs.apar.2018.03.003

M3 - Chapter

SN - 9780128151693

VL - 100

T3 - Advances in Parasitology

SP - 209

EP - 237

BT - Advances in Parasitology

PB - Academic Press

CY - United Kingdom

ER -

Russo Frasca Candido R, Morassutti AL, Graeff-Teixeira C, St Pierre T, Jones MK. Exploring Structural and Physical Properties of Schistosome Eggs: Potential Pathways for Novel Diagnostics. In Advances in Parasitology. Vol. 100. United Kingdom: Academic Press. 2018. p. 209-237. (Advances in Parasitology). https://doi.org/10.1016/bs.apar.2018.03.003