Abstract
Recurrence of primary tumours after surgical resection of solid cancers is still a significant challenge. Understanding what effects the biological and immunological pathways invoked by surgery have on local tumor immune responses can help guide use of immunotherapy. Here, we found that there is a rapid, but transient expression of inflammatory cytokines and an influx of PD-L1+ neutrophils into the tumor/wound. Importantly, the timing of surgery in relation to the administration of ICB drastically altered the outcome, with neoadjuvant therapy significantly increasing the response. Neoadjuvant ICB prevented surgery-induced immune suppression while improving leukocyte migration and CD8+ T-cell activation, which was neutrophil dependent.
| Original language | English |
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| Qualification | Doctor of Philosophy |
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| Award date | 15 Nov 2024 |
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| Publication status | Unpublished - 2024 |
Access to Document
- THESIS - DOCTOR OF PHILOSOPHY - WESTON Breana Judith - 2024_
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