Exploiting sp2-Hybridisation in the Development of Potent 1,5-α-l-Arabinanase Inhibitors

Travis Coyle, Aleksandra W. Debowski, Annabelle Varrot, Keith A. Stubbs

Research output: Contribution to journalArticle

Abstract

The synthesis of potent inhibitors of GH93 arabinanases as well as a synthesis of a chromogenic substrate to measure GH93 arabinanase activity are described. An insight into the reasons behind the potency of the inhibitors was gained through X-ray crystallographic analysis of the arabinanase Arb93A from Fusarium graminearum. These compounds lay a foundation for future inhibitor development as well as for the use of the chromogenic substrate in biochemical studies of GH93 arabinanases.

Original languageEnglish
Pages (from-to)974-978
Number of pages5
JournalChemBioChem
Volume18
Issue number11
DOIs
Publication statusPublished - 1 Jun 2017

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