Experimental modelling of magnetically traceable nanoparticles for the in vivo transport and remotely triggered release of drugs

The principles and feasibility of developing magnetically trackable nanoparticles for the transport, and triggered release of drugs in vivo are investigated. Two different model nanocomposite particle systems are explored, each having in common magnetic iron oxide as a key component. Inclusion of the magnetic iron oxide both enables tracking of the drug carrying particles with magnetic resonance imaging and facilitates deposition of energy into the composite particles via remote irradiation with electromagnetic fields with the intent of triggering release of the drug cargo. Systems based on both mesoporous silica and thermosensitive polymer coatings for the magnetic particles were investigated.