Exosomes—the enigmatic regulators of bone homeostasis

Minhao Gao; Weiyang Gao; J. M. Papadimitriou; Changqing Zhang; Junjie Gao; Minghao Zheng

doi:10.1038/s41413-018-0039-2

Exosomes—the enigmatic regulators of bone homeostasis

Minhao Gao
, Weiyang Gao
, J. M. Papadimitriou
, Changqing Zhang
, Junjie Gao
, Minghao Zheng

Research output: Contribution to journal › Review article › peer-review

117 Citations (Scopus)

Abstract

Exosomes are a heterogeneous group of cell-derived membranous structures, which mediate crosstalk interaction between cells. Recent studies have revealed a close relationship between exosomes and bone homeostasis. It is suggested that bone cells can spontaneously secret exosomes containing proteins, lipids and nucleic acids, which then to regulate osteoclastogenesis and osteogenesis. However, the network of regulatory activities of exosomes in bone homeostasis as well as their therapeutic potential in bone injury remain largely unknown. This review will detail and discuss the characteristics of exosomes, the regulatory activities of exosomes in bone homeostasis as well as the clinical potential of exosomes in bone injury.

Original language	English
Article number	36
Journal	Bone Research
Volume	6
Issue number	1
DOIs	https://doi.org/10.1038/s41413-018-0039-2
Publication status	Published - 1 Dec 2018

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10.1038/s41413-018-0039-2

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title = "Exosomes—the enigmatic regulators of bone homeostasis",

abstract = "Exosomes are a heterogeneous group of cell-derived membranous structures, which mediate crosstalk interaction between cells. Recent studies have revealed a close relationship between exosomes and bone homeostasis. It is suggested that bone cells can spontaneously secret exosomes containing proteins, lipids and nucleic acids, which then to regulate osteoclastogenesis and osteogenesis. However, the network of regulatory activities of exosomes in bone homeostasis as well as their therapeutic potential in bone injury remain largely unknown. This review will detail and discuss the characteristics of exosomes, the regulatory activities of exosomes in bone homeostasis as well as the clinical potential of exosomes in bone injury.",

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AU - Gao, Minhao

AU - Gao, Weiyang

AU - Papadimitriou, J. M.

AU - Zhang, Changqing

AU - Gao, Junjie

AU - Zheng, Minghao

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Exosomes are a heterogeneous group of cell-derived membranous structures, which mediate crosstalk interaction between cells. Recent studies have revealed a close relationship between exosomes and bone homeostasis. It is suggested that bone cells can spontaneously secret exosomes containing proteins, lipids and nucleic acids, which then to regulate osteoclastogenesis and osteogenesis. However, the network of regulatory activities of exosomes in bone homeostasis as well as their therapeutic potential in bone injury remain largely unknown. This review will detail and discuss the characteristics of exosomes, the regulatory activities of exosomes in bone homeostasis as well as the clinical potential of exosomes in bone injury.

AB - Exosomes are a heterogeneous group of cell-derived membranous structures, which mediate crosstalk interaction between cells. Recent studies have revealed a close relationship between exosomes and bone homeostasis. It is suggested that bone cells can spontaneously secret exosomes containing proteins, lipids and nucleic acids, which then to regulate osteoclastogenesis and osteogenesis. However, the network of regulatory activities of exosomes in bone homeostasis as well as their therapeutic potential in bone injury remain largely unknown. This review will detail and discuss the characteristics of exosomes, the regulatory activities of exosomes in bone homeostasis as well as the clinical potential of exosomes in bone injury.

UR - https://www.scopus.com/pages/publications/85058067023

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JF - Bone Research

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ER -

Exosomes—the enigmatic regulators of bone homeostasis

Abstract

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Distinct differences between calvarial and long bone osteocytes in cell morphologies, gene expressions and aging responses

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