Exosomes—the enigmatic regulators of bone homeostasis

Minhao Gao, Weiyang Gao, J. M. Papadimitriou, Changqing Zhang, Junjie Gao, Minghao Zheng

    Research output: Contribution to journalReview article

    5 Citations (Scopus)

    Abstract

    Exosomes are a heterogeneous group of cell-derived membranous structures, which mediate crosstalk interaction between cells. Recent studies have revealed a close relationship between exosomes and bone homeostasis. It is suggested that bone cells can spontaneously secret exosomes containing proteins, lipids and nucleic acids, which then to regulate osteoclastogenesis and osteogenesis. However, the network of regulatory activities of exosomes in bone homeostasis as well as their therapeutic potential in bone injury remain largely unknown. This review will detail and discuss the characteristics of exosomes, the regulatory activities of exosomes in bone homeostasis as well as the clinical potential of exosomes in bone injury.

    Original languageEnglish
    Article number36
    JournalBone Research
    Volume6
    Issue number1
    DOIs
    Publication statusPublished - 1 Dec 2018

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    Exosomes
    Homeostasis
    Bone and Bones
    Osteogenesis
    Wounds and Injuries
    Cell Communication
    Nucleic Acids
    Lipids

    Cite this

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    title = "Exosomes—the enigmatic regulators of bone homeostasis",
    abstract = "Exosomes are a heterogeneous group of cell-derived membranous structures, which mediate crosstalk interaction between cells. Recent studies have revealed a close relationship between exosomes and bone homeostasis. It is suggested that bone cells can spontaneously secret exosomes containing proteins, lipids and nucleic acids, which then to regulate osteoclastogenesis and osteogenesis. However, the network of regulatory activities of exosomes in bone homeostasis as well as their therapeutic potential in bone injury remain largely unknown. This review will detail and discuss the characteristics of exosomes, the regulatory activities of exosomes in bone homeostasis as well as the clinical potential of exosomes in bone injury.",
    author = "Minhao Gao and Weiyang Gao and Papadimitriou, {J. M.} and Changqing Zhang and Junjie Gao and Minghao Zheng",
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    Exosomes—the enigmatic regulators of bone homeostasis. / Gao, Minhao; Gao, Weiyang; Papadimitriou, J. M.; Zhang, Changqing; Gao, Junjie; Zheng, Minghao.

    In: Bone Research, Vol. 6, No. 1, 36, 01.12.2018.

    Research output: Contribution to journalReview article

    TY - JOUR

    T1 - Exosomes—the enigmatic regulators of bone homeostasis

    AU - Gao, Minhao

    AU - Gao, Weiyang

    AU - Papadimitriou, J. M.

    AU - Zhang, Changqing

    AU - Gao, Junjie

    AU - Zheng, Minghao

    PY - 2018/12/1

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    N2 - Exosomes are a heterogeneous group of cell-derived membranous structures, which mediate crosstalk interaction between cells. Recent studies have revealed a close relationship between exosomes and bone homeostasis. It is suggested that bone cells can spontaneously secret exosomes containing proteins, lipids and nucleic acids, which then to regulate osteoclastogenesis and osteogenesis. However, the network of regulatory activities of exosomes in bone homeostasis as well as their therapeutic potential in bone injury remain largely unknown. This review will detail and discuss the characteristics of exosomes, the regulatory activities of exosomes in bone homeostasis as well as the clinical potential of exosomes in bone injury.

    AB - Exosomes are a heterogeneous group of cell-derived membranous structures, which mediate crosstalk interaction between cells. Recent studies have revealed a close relationship between exosomes and bone homeostasis. It is suggested that bone cells can spontaneously secret exosomes containing proteins, lipids and nucleic acids, which then to regulate osteoclastogenesis and osteogenesis. However, the network of regulatory activities of exosomes in bone homeostasis as well as their therapeutic potential in bone injury remain largely unknown. This review will detail and discuss the characteristics of exosomes, the regulatory activities of exosomes in bone homeostasis as well as the clinical potential of exosomes in bone injury.

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