Exogenous Cell Stimulation: A Versatile Approach to Programming Gene Expression

Research output: ThesisDoctoral Thesis

43 Downloads (Pure)

Abstract

The modulation of transcription to regulate cell function is an important component of modern therapeutic approaches for complex diseases such as cancer and neurodegeneration. In this thesis, different forms of exogenous energetic stimuli were investigated and their effects on the transcriptome and dynamics of human cells characterised. Electrical stimulation using organic substrates was used to promote expression of neuronal genes and enhance differentiation. Unique effects of 60 GHz millimetre waves on gene expression were characterised and correlated with novel interactions with DNA secondary structures. Finally, modulation of secondary structures to regulate chromatin dynamics and gene expression were investigated.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Swaminatha Iyer, Killugudi, Supervisor
  • Wallace, Vince, Supervisor
Thesis sponsors
Award date16 Nov 2023
DOIs
Publication statusUnpublished - 2023

Fingerprint

Dive into the research topics of 'Exogenous Cell Stimulation: A Versatile Approach to Programming Gene Expression'. Together they form a unique fingerprint.

Cite this