Exhaled breath condensate cysteinyl leukotrienes and airway remodeling in childhood asthma: a pilot study

C. Lex, A. Zacharasiewica, Donald Payne, N.M. Wilson, A.G. Nicholson, S.A. Kharitonov, P.J. Barnes, A. Bush

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    Abstract

    BackgroundIt has been suggested that cysteinyl leukotrienes (cysLTs) play an important role in airway remodeling. Previous reports have indicated that cysLTs augment human airway smooth muscle cell proliferation. Recently, cysLTs have been measured in exhaled breath condensate (EBC). The aim of this study was to evaluate the relationship between cysLTs in EBC and another marker of airway remodeling, reticular basement membrane (RBM) thickening, in endobronchial biopsies in children.Methods29 children, aged 4–15 years, with moderate to severe persistent asthma, who underwent bronchoscopy as part of their clinical assessment, were included. Subjects underwent spirometry and EBC collection for cysLTs analysis, followed by bronchoscopy and endobronchial biopsy within 24 hours.ResultsEBC cysLTs were significantly lower in asthmatic children who were treated with montelukast than in those who were not (median (interquartile range) 36.62 (22.60–101.05) versus 249.1 (74.21–526.36) pg/ml, p = 0.004). There was a significant relationship between EBC cysLTs and RBM thickness in the subgroup of children who were not treated with montelukast (n = 13, r = 0.75, p = 0.003).ConclusionEBC cysLTs appear to be associated with RBM thickening in asthma.
    Original languageEnglish
    Pages (from-to)1-7
    JournalRespiratory Research
    Volume7
    Issue number1
    DOIs
    Publication statusPublished - 2006

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    Lex, C., Zacharasiewica, A., Payne, D., Wilson, N. M., Nicholson, A. G., Kharitonov, S. A., ... Bush, A. (2006). Exhaled breath condensate cysteinyl leukotrienes and airway remodeling in childhood asthma: a pilot study. Respiratory Research, 7(1), 1-7. https://doi.org/10.1186/1465-9921-7-63