Exercise training, vascular function and functional capacity in middle-aged subjects.

A. Maiorana, Gerry O'Driscoll, L. Dembo, Carmel Goodman, R.R. Taylor, Daniel Green

Research output: Contribution to journalArticlepeer-review

85 Citations (Scopus)


Purpose: The aim of this study Aas to investigate the effect of 8 wk of exercise training on functional capacity. muscular strength, body composition, and vascular function in sedentary but healthy subjects by using a randomized. crossover protocol, Methods: After familiarization sessions. 19 subjects aged 47 +/- 2 yr (mean : SE) undertook a randomized. crossover design study of the effect of 8 wk of supervised circuit training consisting of combined aerobic and resistance exercise. Peak oxygen uptake ((V) over dot O-2peak). sum of 7 maximal voluntary contractions and the sum of 8 skinfolds and 5 segment girths vv ere determined at entry, crossover. and 16 Ak. Endothelium-dependent and -independent vascular function were determined by forearm strain-gauge plethysmography and intrabrachial infusions of acetylcholine (ACh) and sodium nitroprusside (SNP) in 16 subjects. Results: Training did not alter ACh or SNP responses. (V) over dot O-2peak (28.6 +/- 1.1 to 32.6 +/- 1.3 mL(.)kg(-1.)mm(-1), P <0.001), exercise test duration (17.4 +/- 1.1 to 22.1 +/- 1.2 min, P <0.001), and muscular strength (465 +/- 27 to 535 +/- 27 kg, P
Original languageEnglish
Pages (from-to)2022-2028
JournalMedicine and Science in Sports and Exercise
Publication statusPublished - 2001


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