TY - JOUR
T1 - Exercise for Primary and Secondary Prevention of Cardiovascular Disease
T2 - JACC Focus Seminar 1/4
AU - Tucker, Wesley J.
AU - Fegers-Wustrow, Isabel
AU - Halle, Martin
AU - Haykowsky, Mark J.
AU - Chung, Eugene H.
AU - Kovacic, Jason C.
N1 - Funding Information:
Dr Kovacic is the recipient of an Agilent Thought Leader Award (January 2022), which includes funding for research that is unrelated to the current paper; and has received research support from the National Institutes of Health (R01HL148167), New South Wales health grant RG194194, the Bourne Foundation, and Agilent. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Publisher Copyright:
© 2022 American College of Cardiology Foundation
PY - 2022/9/13
Y1 - 2022/9/13
N2 - Regular exercise that meets or exceeds the current physical activity guidelines is associated with a reduced risk of cardiovascular disease (CVD) and mortality. Therefore, exercise training plays an important role in primary and secondary prevention of CVD. In this part 1 of a 4-part focus seminar series, we highlight the mechanisms and physiological adaptations responsible for the cardioprotective effects of exercise. This includes an increase in cardiorespiratory fitness secondary to cardiac, vascular, and skeletal muscle adaptations and an improvement in traditional and nontraditional CVD risk factors by exercise training. This extends to the role of exercise and its prescription in patients with CVDs (eg, coronary artery disease, chronic heart failure, peripheral artery disease, or atrial fibrillation) with special focus on the optimal mode, dosage, duration, and intensity of exercise to reduce CVD risk and improve clinical outcomes in these patients.
AB - Regular exercise that meets or exceeds the current physical activity guidelines is associated with a reduced risk of cardiovascular disease (CVD) and mortality. Therefore, exercise training plays an important role in primary and secondary prevention of CVD. In this part 1 of a 4-part focus seminar series, we highlight the mechanisms and physiological adaptations responsible for the cardioprotective effects of exercise. This includes an increase in cardiorespiratory fitness secondary to cardiac, vascular, and skeletal muscle adaptations and an improvement in traditional and nontraditional CVD risk factors by exercise training. This extends to the role of exercise and its prescription in patients with CVDs (eg, coronary artery disease, chronic heart failure, peripheral artery disease, or atrial fibrillation) with special focus on the optimal mode, dosage, duration, and intensity of exercise to reduce CVD risk and improve clinical outcomes in these patients.
KW - atrial fibrillation
KW - cardiorespiratory fitness
KW - cardiovascular disease
KW - cardiovascular risk factors
KW - heart failure
KW - mortality
KW - physical activity
UR - http://www.scopus.com/inward/record.url?scp=85136471850&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2022.07.004
DO - 10.1016/j.jacc.2022.07.004
M3 - Review article
C2 - 36075680
AN - SCOPUS:85136471850
SN - 0735-1097
VL - 80
SP - 1091
EP - 1106
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 11
ER -
