Exercise effects on muscle quality in older adults: a systematic review and meta-analysis

Régis Radaelli; Dennis R Taaffe; Robert U Newton; Daniel A Galvão; Pedro Lopez

doi:10.1038/s41598-021-00600-3

Exercise effects on muscle quality in older adults: a systematic review and meta-analysis

Régis Radaelli, Dennis R Taaffe, Robert U Newton, Daniel A Galvão, Pedro Lopez

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

To systematically review and analyse the effects of exercise on morphological and neuromuscular muscle quality (MQ) outcomes in older adults and assess a range of possible moderators that may affect the impact of exercise on MQ outcomes. Using PRISMA guidelines, randomised controlled trials were searched in CINAHL, EMBASE, LILACS, PubMed, SciELO, Web of Science, MedNar, OpenGrey and OpenThesis databases. Eligible trials examined the effects of exercise interventions on morphological and neuromuscular MQ in older adults (≥ 60 years). Twenty-one trials (n = 973 participants) were included. Exercise significantly improved morphological MQ (effect size (ES) = 0.32, 95% CI 0.13-0.51, P 0.05). Supervised exercise interventions significantly improved different measures of MQ regardless of exercise duration, although these effects were small-to-moderate and not supported across all population-, exercise-, and methods-related features.

Original language	English
Article number	21085
Journal	Scientific Reports
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41598-021-00600-3
Publication status	Published - 26 Oct 2021
Externally published	Yes

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title = "Exercise effects on muscle quality in older adults: a systematic review and meta-analysis",

abstract = "To systematically review and analyse the effects of exercise on morphological and neuromuscular muscle quality (MQ) outcomes in older adults and assess a range of possible moderators that may affect the impact of exercise on MQ outcomes. Using PRISMA guidelines, randomised controlled trials were searched in CINAHL, EMBASE, LILACS, PubMed, SciELO, Web of Science, MedNar, OpenGrey and OpenThesis databases. Eligible trials examined the effects of exercise interventions on morphological and neuromuscular MQ in older adults (≥ 60 years). Twenty-one trials (n = 973 participants) were included. Exercise significantly improved morphological MQ (effect size (ES) = 0.32, 95\% CI 0.13-0.51, P 0.05). Supervised exercise interventions significantly improved different measures of MQ regardless of exercise duration, although these effects were small-to-moderate and not supported across all population-, exercise-, and methods-related features.",

keywords = "Adipose Tissue, Aged, Exercise, Humans, Muscle Strength, Muscle, Skeletal",

author = "R{\'e}gis Radaelli and Taaffe, \{Dennis R\} and Newton, \{Robert U\} and Galv{\~a}o, \{Daniel A\} and Pedro Lopez",

note = "Funding Information: Pedro Lopez is supported by the National Health and Medical Research. Council (NHMRC) Centre of Research Excellence (CRE) in Prostate Cancer Survivorship. Scholarship. Daniel A. Galv{\~a}o and Robert U. Newton are funded by a NHMRC CRE in Prostate Cancer Survivorship. The results of the study are presented clearly, honestly, without fabrication, falsification, or inappropriate data manipulation, and do not constitute endorsement by the American College of Sports Medicine. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

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doi = "10.1038/s41598-021-00600-3",

language = "English",

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AU - Radaelli, Régis

AU - Taaffe, Dennis R

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AU - Lopez, Pedro

N1 - Funding Information: Pedro Lopez is supported by the National Health and Medical Research. Council (NHMRC) Centre of Research Excellence (CRE) in Prostate Cancer Survivorship. Scholarship. Daniel A. Galvão and Robert U. Newton are funded by a NHMRC CRE in Prostate Cancer Survivorship. The results of the study are presented clearly, honestly, without fabrication, falsification, or inappropriate data manipulation, and do not constitute endorsement by the American College of Sports Medicine. Publisher Copyright: © 2021, The Author(s).

PY - 2021/10/26

Y1 - 2021/10/26

N2 - To systematically review and analyse the effects of exercise on morphological and neuromuscular muscle quality (MQ) outcomes in older adults and assess a range of possible moderators that may affect the impact of exercise on MQ outcomes. Using PRISMA guidelines, randomised controlled trials were searched in CINAHL, EMBASE, LILACS, PubMed, SciELO, Web of Science, MedNar, OpenGrey and OpenThesis databases. Eligible trials examined the effects of exercise interventions on morphological and neuromuscular MQ in older adults (≥ 60 years). Twenty-one trials (n = 973 participants) were included. Exercise significantly improved morphological MQ (effect size (ES) = 0.32, 95% CI 0.13-0.51, P 0.05). Supervised exercise interventions significantly improved different measures of MQ regardless of exercise duration, although these effects were small-to-moderate and not supported across all population-, exercise-, and methods-related features.

AB - To systematically review and analyse the effects of exercise on morphological and neuromuscular muscle quality (MQ) outcomes in older adults and assess a range of possible moderators that may affect the impact of exercise on MQ outcomes. Using PRISMA guidelines, randomised controlled trials were searched in CINAHL, EMBASE, LILACS, PubMed, SciELO, Web of Science, MedNar, OpenGrey and OpenThesis databases. Eligible trials examined the effects of exercise interventions on morphological and neuromuscular MQ in older adults (≥ 60 years). Twenty-one trials (n = 973 participants) were included. Exercise significantly improved morphological MQ (effect size (ES) = 0.32, 95% CI 0.13-0.51, P 0.05). Supervised exercise interventions significantly improved different measures of MQ regardless of exercise duration, although these effects were small-to-moderate and not supported across all population-, exercise-, and methods-related features.

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KW - Exercise

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KW - Muscle Strength

KW - Muscle, Skeletal

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DO - 10.1038/s41598-021-00600-3

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VL - 11

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 21085

ER -

Exercise effects on muscle quality in older adults: a systematic review and meta-analysis

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