Exercise augments weight loss induced improvement in renal function in obese metabolic syndrome individuals

Nora E. Straznicky, Mariee T. Grima, Elisabeth A. Lambert, Nina Eikelis, Tye Dawood, Gavin W. Lambert, Paul J. Nestel, Kazuko Masuo, Carolina I. Sari, Reena Chopra, Justin A. Mariani, Markus P. Schlaich

Research output: Contribution to journalArticle

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Abstract

Objective: Metabolic syndrome (MetS) obesity is an independent risk factor for chronic kidney disease. This study was conducted to examine the effects of lifestyle interventions on renal parameters and putative metabolic, neuroadrenergic and hemodynamic mediators of renal injury. Methods: Untreated men and women (mean age 55 ± 1 years; BMI 32.7 ± 0.6 kg/m) without pre-existing renal dysfunction, who fulfilled MetS criteria were randomized to dietary weight loss (WL, n = 13), weight loss combined with aerobic exercise (WL + EX, n = 13), or no treatment (control, n = 12). Estimated glomerular filtration rate (eGFR), 24 h urinary albumin excretion, plasma renin activity (PRA), muscle sympathetic nerve activity (MSNA), baroreflex sensitivity (BRS), anthropometric, metabolic and fitness variables were measured at baseline and week 12. Results: Body weight decreased by -8.2 ± 0.8% in the WL and -10.7 ± 0.9% in the WL + EX groups (both P < 0.001). Fitness (maximal oxygen consumption) increased by 15 ± 5% and BRS by 5.5 ± 2.4 ms/mmHg in the WL + EX group only (P < 0.05). Serum creatinine decreased by -8.1 ± 4.8%, (WL, P = 0.016) and -14.9 ± 3.0% (WL + EX, P < 0.001). Estimated GFR increased commensurately but the increment was greater in the WL + EX group (P = 0.04). Albuminuria (P < 0.05) and MSNA (P < 0.001) decreased similarly in both groups, whereas PRA, high sensitivity C-reactive protein, uric acid and DBP decreased only in the WL + EX group (all P < 0.05). Conclusion: Moderate weight loss in obese MetS patients is associated with a reduction in albuminuria and an improvement in eGFR which is augmented by exercise co-intervention.

Original languageEnglish
Pages (from-to)553-564
Number of pages12
JournalJournal of Hypertension
Volume29
Issue number3
DOIs
Publication statusPublished - 1 Mar 2011
Externally publishedYes

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Weight Loss
Albuminuria
Baroreflex
Exercise
Glomerular Filtration Rate
Kidney
Renin
Muscles
Uric Acid
Chronic Renal Insufficiency
Oxygen Consumption
Serum Albumin
C-Reactive Protein
Life Style
Creatinine
Obesity
Hemodynamics
Body Weight
Wounds and Injuries
Serum

Cite this

Straznicky, Nora E. ; Grima, Mariee T. ; Lambert, Elisabeth A. ; Eikelis, Nina ; Dawood, Tye ; Lambert, Gavin W. ; Nestel, Paul J. ; Masuo, Kazuko ; Sari, Carolina I. ; Chopra, Reena ; Mariani, Justin A. ; Schlaich, Markus P. / Exercise augments weight loss induced improvement in renal function in obese metabolic syndrome individuals. In: Journal of Hypertension. 2011 ; Vol. 29, No. 3. pp. 553-564.
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abstract = "Objective: Metabolic syndrome (MetS) obesity is an independent risk factor for chronic kidney disease. This study was conducted to examine the effects of lifestyle interventions on renal parameters and putative metabolic, neuroadrenergic and hemodynamic mediators of renal injury. Methods: Untreated men and women (mean age 55 ± 1 years; BMI 32.7 ± 0.6 kg/m) without pre-existing renal dysfunction, who fulfilled MetS criteria were randomized to dietary weight loss (WL, n = 13), weight loss combined with aerobic exercise (WL + EX, n = 13), or no treatment (control, n = 12). Estimated glomerular filtration rate (eGFR), 24 h urinary albumin excretion, plasma renin activity (PRA), muscle sympathetic nerve activity (MSNA), baroreflex sensitivity (BRS), anthropometric, metabolic and fitness variables were measured at baseline and week 12. Results: Body weight decreased by -8.2 ± 0.8{\%} in the WL and -10.7 ± 0.9{\%} in the WL + EX groups (both P < 0.001). Fitness (maximal oxygen consumption) increased by 15 ± 5{\%} and BRS by 5.5 ± 2.4 ms/mmHg in the WL + EX group only (P < 0.05). Serum creatinine decreased by -8.1 ± 4.8{\%}, (WL, P = 0.016) and -14.9 ± 3.0{\%} (WL + EX, P < 0.001). Estimated GFR increased commensurately but the increment was greater in the WL + EX group (P = 0.04). Albuminuria (P < 0.05) and MSNA (P < 0.001) decreased similarly in both groups, whereas PRA, high sensitivity C-reactive protein, uric acid and DBP decreased only in the WL + EX group (all P < 0.05). Conclusion: Moderate weight loss in obese MetS patients is associated with a reduction in albuminuria and an improvement in eGFR which is augmented by exercise co-intervention.",
keywords = "aerobic exercise, albuminuria, metabolic syndrome, obesity, renal function, sympathetic nervous system, weight loss",
author = "Straznicky, {Nora E.} and Grima, {Mariee T.} and Lambert, {Elisabeth A.} and Nina Eikelis and Tye Dawood and Lambert, {Gavin W.} and Nestel, {Paul J.} and Kazuko Masuo and Sari, {Carolina I.} and Reena Chopra and Mariani, {Justin A.} and Schlaich, {Markus P.}",
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Straznicky, NE, Grima, MT, Lambert, EA, Eikelis, N, Dawood, T, Lambert, GW, Nestel, PJ, Masuo, K, Sari, CI, Chopra, R, Mariani, JA & Schlaich, MP 2011, 'Exercise augments weight loss induced improvement in renal function in obese metabolic syndrome individuals' Journal of Hypertension, vol. 29, no. 3, pp. 553-564. https://doi.org/10.1097/HJH.0b013e3283418875

Exercise augments weight loss induced improvement in renal function in obese metabolic syndrome individuals. / Straznicky, Nora E.; Grima, Mariee T.; Lambert, Elisabeth A.; Eikelis, Nina; Dawood, Tye; Lambert, Gavin W.; Nestel, Paul J.; Masuo, Kazuko; Sari, Carolina I.; Chopra, Reena; Mariani, Justin A.; Schlaich, Markus P.

In: Journal of Hypertension, Vol. 29, No. 3, 01.03.2011, p. 553-564.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Exercise augments weight loss induced improvement in renal function in obese metabolic syndrome individuals

AU - Straznicky, Nora E.

AU - Grima, Mariee T.

AU - Lambert, Elisabeth A.

AU - Eikelis, Nina

AU - Dawood, Tye

AU - Lambert, Gavin W.

AU - Nestel, Paul J.

AU - Masuo, Kazuko

AU - Sari, Carolina I.

AU - Chopra, Reena

AU - Mariani, Justin A.

AU - Schlaich, Markus P.

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Objective: Metabolic syndrome (MetS) obesity is an independent risk factor for chronic kidney disease. This study was conducted to examine the effects of lifestyle interventions on renal parameters and putative metabolic, neuroadrenergic and hemodynamic mediators of renal injury. Methods: Untreated men and women (mean age 55 ± 1 years; BMI 32.7 ± 0.6 kg/m) without pre-existing renal dysfunction, who fulfilled MetS criteria were randomized to dietary weight loss (WL, n = 13), weight loss combined with aerobic exercise (WL + EX, n = 13), or no treatment (control, n = 12). Estimated glomerular filtration rate (eGFR), 24 h urinary albumin excretion, plasma renin activity (PRA), muscle sympathetic nerve activity (MSNA), baroreflex sensitivity (BRS), anthropometric, metabolic and fitness variables were measured at baseline and week 12. Results: Body weight decreased by -8.2 ± 0.8% in the WL and -10.7 ± 0.9% in the WL + EX groups (both P < 0.001). Fitness (maximal oxygen consumption) increased by 15 ± 5% and BRS by 5.5 ± 2.4 ms/mmHg in the WL + EX group only (P < 0.05). Serum creatinine decreased by -8.1 ± 4.8%, (WL, P = 0.016) and -14.9 ± 3.0% (WL + EX, P < 0.001). Estimated GFR increased commensurately but the increment was greater in the WL + EX group (P = 0.04). Albuminuria (P < 0.05) and MSNA (P < 0.001) decreased similarly in both groups, whereas PRA, high sensitivity C-reactive protein, uric acid and DBP decreased only in the WL + EX group (all P < 0.05). Conclusion: Moderate weight loss in obese MetS patients is associated with a reduction in albuminuria and an improvement in eGFR which is augmented by exercise co-intervention.

AB - Objective: Metabolic syndrome (MetS) obesity is an independent risk factor for chronic kidney disease. This study was conducted to examine the effects of lifestyle interventions on renal parameters and putative metabolic, neuroadrenergic and hemodynamic mediators of renal injury. Methods: Untreated men and women (mean age 55 ± 1 years; BMI 32.7 ± 0.6 kg/m) without pre-existing renal dysfunction, who fulfilled MetS criteria were randomized to dietary weight loss (WL, n = 13), weight loss combined with aerobic exercise (WL + EX, n = 13), or no treatment (control, n = 12). Estimated glomerular filtration rate (eGFR), 24 h urinary albumin excretion, plasma renin activity (PRA), muscle sympathetic nerve activity (MSNA), baroreflex sensitivity (BRS), anthropometric, metabolic and fitness variables were measured at baseline and week 12. Results: Body weight decreased by -8.2 ± 0.8% in the WL and -10.7 ± 0.9% in the WL + EX groups (both P < 0.001). Fitness (maximal oxygen consumption) increased by 15 ± 5% and BRS by 5.5 ± 2.4 ms/mmHg in the WL + EX group only (P < 0.05). Serum creatinine decreased by -8.1 ± 4.8%, (WL, P = 0.016) and -14.9 ± 3.0% (WL + EX, P < 0.001). Estimated GFR increased commensurately but the increment was greater in the WL + EX group (P = 0.04). Albuminuria (P < 0.05) and MSNA (P < 0.001) decreased similarly in both groups, whereas PRA, high sensitivity C-reactive protein, uric acid and DBP decreased only in the WL + EX group (all P < 0.05). Conclusion: Moderate weight loss in obese MetS patients is associated with a reduction in albuminuria and an improvement in eGFR which is augmented by exercise co-intervention.

KW - aerobic exercise

KW - albuminuria

KW - metabolic syndrome

KW - obesity

KW - renal function

KW - sympathetic nervous system

KW - weight loss

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U2 - 10.1097/HJH.0b013e3283418875

DO - 10.1097/HJH.0b013e3283418875

M3 - Article

VL - 29

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EP - 564

JO - Journal of Hypertension.

JF - Journal of Hypertension.

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