Exercise and vascular function in child obesity: A meta-analysis

K.A. Dias, Daniel J Green, C.B. Ingul, T.G. Pavey, J.S. Coombes

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


© 2015 by the American Academy of Pediatrics. CONTEXT: Conduit artery flow-mediated dilation (FMD) is a noninvasive index of preclinical atherosclerosis in humans. Exercise interventions can improve FMD in both healthy and clinical populations. OBJECTIVE: This systematic review and meta-analysis aimed to summarize the effect of exercise training on FMD in overweight and obese children and adolescents as well as investigate the role of cardiorespiratory fitness (peak oxygen consumption [VO2peak]) on effects observed. DATA SOURCES: PubMed, Medline, Embase, and Cinahl databases were searched from the earliest available date to February 2015. STUDY SELECTION: Studies of children and/or adolescents who were overweight or obese were included. DATA EXTRACTION: Standardized data extraction forms were used for patient and intervention characteristics, control/comparator groups, and key outcomes. Procedural quality of the studies was assessed using a modified version of the Physiotherapy Evidence Base Database scale. RESULTS: A meta-analysis involving 219 participants compared the mean difference of preversus postintervention vascular function (FMD) and VO2peak between an exercise training intervention and a control condition. There was a significantly greater improvement in FMD (mean difference 1.54%, P 2peak (mean difference 3.64 mL/kg/min, P
Original languageEnglish
Pages (from-to)e648-e659
Issue number3
Publication statusPublished - 2015


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