Exclusion of linkage to the HLA region in ninety multiplex sibships with autism

T. Rogers; L. Kalaydjieva; J. Hallmayer; P.B. Petersen; P. Nicholas; C. Pingree; W.M. Mcmahon; D. Spiker; L. Lotspeich; H. Kraemer; P. Mccague; S. Dimiceli; N. Nouri; T. Peachy; J. Yang; D. Hinds; N. Risch; R.M. Myers

doi:10.1023/A:1023075904742

Exclusion of linkage to the HLA region in ninety multiplex sibships with autism

T. Rogers, L. Kalaydjieva, J. Hallmayer, P.B. Petersen, P. Nicholas, C. Pingree, W.M. Mcmahon, D. Spiker, L. Lotspeich, H. Kraemer, P. Mccague, S. Dimiceli, N. Nouri, T. Peachy, J. Yang, D. Hinds, N. Risch, R.M. Myers

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Abstract

Several studies have suggested a role for the histocompatibility complex of loci (HLA) in the genetic susceptibility to autism. We have tested this hypothesis by linkage analysis using genetic marker loci in the HLA region on chromosome 6p in multiplex families with autism. We have examined sharing of alleles identical by descent in 97 affected sib pairs from 90 families. Results demonstrate no deviation from the null expectation of 50% sharing of alleles in this region; in fact, for most marker loci, the observed sharing was less than 50%. Thus, it is unlikely that loci in this region contribute to the genetic etiology of autism to any significant extent in our families.

Original language	English
Pages (from-to)	195-201
Journal	Journal of Autism and Developmental Disorders
Volume	29
Issue number	3
DOIs	https://doi.org/10.1023/A:1023075904742
Publication status	Published - 1999

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Rogers, T., Kalaydjieva, L., Hallmayer, J., Petersen, P. B., Nicholas, P., Pingree, C., Mcmahon, W. M., Spiker, D., Lotspeich, L., Kraemer, H., Mccague, P., Dimiceli, S., Nouri, N., Peachy, T., Yang, J., Hinds, D., Risch, N., & Myers, R. M. (1999). Exclusion of linkage to the HLA region in ninety multiplex sibships with autism. Journal of Autism and Developmental Disorders, 29(3), 195-201. https://doi.org/10.1023/A:1023075904742

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title = "Exclusion of linkage to the HLA region in ninety multiplex sibships with autism",

abstract = "Several studies have suggested a role for the histocompatibility complex of loci (HLA) in the genetic susceptibility to autism. We have tested this hypothesis by linkage analysis using genetic marker loci in the HLA region on chromosome 6p in multiplex families with autism. We have examined sharing of alleles identical by descent in 97 affected sib pairs from 90 families. Results demonstrate no deviation from the null expectation of 50% sharing of alleles in this region; in fact, for most marker loci, the observed sharing was less than 50%. Thus, it is unlikely that loci in this region contribute to the genetic etiology of autism to any significant extent in our families.",

author = "T. Rogers and L. Kalaydjieva and J. Hallmayer and P.B. Petersen and P. Nicholas and C. Pingree and W.M. Mcmahon and D. Spiker and L. Lotspeich and H. Kraemer and P. Mccague and S. Dimiceli and N. Nouri and T. Peachy and J. Yang and D. Hinds and N. Risch and R.M. Myers",

year = "1999",

doi = "10.1023/A:1023075904742",

language = "English",

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Rogers, T, Kalaydjieva, L, Hallmayer, J, Petersen, PB, Nicholas, P, Pingree, C, Mcmahon, WM, Spiker, D, Lotspeich, L, Kraemer, H, Mccague, P, Dimiceli, S, Nouri, N, Peachy, T, Yang, J, Hinds, D, Risch, N & Myers, RM 1999, 'Exclusion of linkage to the HLA region in ninety multiplex sibships with autism', Journal of Autism and Developmental Disorders, vol. 29, no. 3, pp. 195-201. https://doi.org/10.1023/A:1023075904742

TY - JOUR

T1 - Exclusion of linkage to the HLA region in ninety multiplex sibships with autism

AU - Rogers, T.

AU - Kalaydjieva, L.

AU - Hallmayer, J.

AU - Petersen, P.B.

AU - Nicholas, P.

AU - Pingree, C.

AU - Mcmahon, W.M.

AU - Spiker, D.

AU - Lotspeich, L.

AU - Kraemer, H.

AU - Mccague, P.

AU - Dimiceli, S.

AU - Nouri, N.

AU - Peachy, T.

AU - Yang, J.

AU - Hinds, D.

AU - Risch, N.

AU - Myers, R.M.

PY - 1999

Y1 - 1999

N2 - Several studies have suggested a role for the histocompatibility complex of loci (HLA) in the genetic susceptibility to autism. We have tested this hypothesis by linkage analysis using genetic marker loci in the HLA region on chromosome 6p in multiplex families with autism. We have examined sharing of alleles identical by descent in 97 affected sib pairs from 90 families. Results demonstrate no deviation from the null expectation of 50% sharing of alleles in this region; in fact, for most marker loci, the observed sharing was less than 50%. Thus, it is unlikely that loci in this region contribute to the genetic etiology of autism to any significant extent in our families.

AB - Several studies have suggested a role for the histocompatibility complex of loci (HLA) in the genetic susceptibility to autism. We have tested this hypothesis by linkage analysis using genetic marker loci in the HLA region on chromosome 6p in multiplex families with autism. We have examined sharing of alleles identical by descent in 97 affected sib pairs from 90 families. Results demonstrate no deviation from the null expectation of 50% sharing of alleles in this region; in fact, for most marker loci, the observed sharing was less than 50%. Thus, it is unlikely that loci in this region contribute to the genetic etiology of autism to any significant extent in our families.

U2 - 10.1023/A:1023075904742

DO - 10.1023/A:1023075904742

M3 - Article

SN - 0162-3257

VL - 29

SP - 195

EP - 201

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

IS - 3

ER -

Exclusion of linkage to the HLA region in ninety multiplex sibships with autism

Abstract

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