Excessive alcohol comsumption increases mortality in later life: a genetic analysis of the health in men cohort study

Osvaldo Almeida, Kieran Mccaul, Graeme Hankey, Bu Yeap, J. Golledge, Leon Flicker

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Abstract

We designed this cohort study of men aged 70–89 years to determine if excessive alcohol use increases mortality. They reported history of alcohol use (never, past, ≤ two daily drinks, two to four daily drinks, four to six daily drinks, > six daily drinks) and donated a blood sample in 2001–2004. We determined the ADH1B rs1229984 G>A polymorphism and retrieved mortality data from the Western Australian Data Linkage System. Other study measures included age, education, body mass index, smoking, and history of hypertension, diabetes, chronic respiratory diseases, coronary heart disease and stroke. Of the 3496 participants, 225 (6.4 percent) carried the ADH1B rs1229984 G>A polymorphism. Carriers consumed significantly less alcohol than non‐carriers. The adjusted mortality hazard ratio (MHR, 95 percent confidence interval—95%CI) over 8.0 years (range: 10 weeks to 11.2 years) relative to never drinkers was 1.15 (95%CI = 0.86, 1.55) for past drinkers, 0.98 (95%CI = 0.76, 1.25) for men consuming ≤ two daily drinks, 1.13 (95%CI = 0.85, 1.49) for two to four drinks, 1.18 (95%CI = 0.81, 1.71) for four to six drinks and 1.87 (95%CI = 1.11, 3.12) for those consuming more than six daily drinks on a regular basis. The MHR associated with the ADH1B rs1229984 G>A polymorphism was 0.68 (95%CI = 0.54, 0.87). Excessive alcohol use in later life is associated with increased mortality, and this association is likely to be causal. We found no evidence that light to moderate alcohol use decreases the mortality of older men. Health messages regarding the safe use of alcohol in older age may benefit from taking these findings into account.
Original languageEnglish
Pages (from-to)570-578
JournalAddiction Biology
Volume22
Issue number2
DOIs
Publication statusPublished - Mar 2017

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Men's Health
Cohort Studies
Alcohols
Mortality
Information Storage and Retrieval
Information Systems
Coronary Disease
Body Mass Index
Chronic Disease
Smoking
Stroke
Hypertension
Education
Light
Health

Cite this

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title = "Excessive alcohol comsumption increases mortality in later life: a genetic analysis of the health in men cohort study",
abstract = "We designed this cohort study of men aged 70–89 years to determine if excessive alcohol use increases mortality. They reported history of alcohol use (never, past, ≤ two daily drinks, two to four daily drinks, four to six daily drinks, > six daily drinks) and donated a blood sample in 2001–2004. We determined the ADH1B rs1229984 G>A polymorphism and retrieved mortality data from the Western Australian Data Linkage System. Other study measures included age, education, body mass index, smoking, and history of hypertension, diabetes, chronic respiratory diseases, coronary heart disease and stroke. Of the 3496 participants, 225 (6.4 percent) carried the ADH1B rs1229984 G>A polymorphism. Carriers consumed significantly less alcohol than non‐carriers. The adjusted mortality hazard ratio (MHR, 95 percent confidence interval—95{\%}CI) over 8.0 years (range: 10 weeks to 11.2 years) relative to never drinkers was 1.15 (95{\%}CI = 0.86, 1.55) for past drinkers, 0.98 (95{\%}CI = 0.76, 1.25) for men consuming ≤ two daily drinks, 1.13 (95{\%}CI = 0.85, 1.49) for two to four drinks, 1.18 (95{\%}CI = 0.81, 1.71) for four to six drinks and 1.87 (95{\%}CI = 1.11, 3.12) for those consuming more than six daily drinks on a regular basis. The MHR associated with the ADH1B rs1229984 G>A polymorphism was 0.68 (95{\%}CI = 0.54, 0.87). Excessive alcohol use in later life is associated with increased mortality, and this association is likely to be causal. We found no evidence that light to moderate alcohol use decreases the mortality of older men. Health messages regarding the safe use of alcohol in older age may benefit from taking these findings into account.",
author = "Osvaldo Almeida and Kieran Mccaul and Graeme Hankey and Bu Yeap and J. Golledge and Leon Flicker",
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Excessive alcohol comsumption increases mortality in later life: a genetic analysis of the health in men cohort study. / Almeida, Osvaldo; Mccaul, Kieran; Hankey, Graeme; Yeap, Bu; Golledge, J.; Flicker, Leon.

In: Addiction Biology, Vol. 22, No. 2, 03.2017, p. 570-578.

Research output: Contribution to journalArticle

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T1 - Excessive alcohol comsumption increases mortality in later life: a genetic analysis of the health in men cohort study

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AU - Mccaul, Kieran

AU - Hankey, Graeme

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AU - Golledge, J.

AU - Flicker, Leon

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N2 - We designed this cohort study of men aged 70–89 years to determine if excessive alcohol use increases mortality. They reported history of alcohol use (never, past, ≤ two daily drinks, two to four daily drinks, four to six daily drinks, > six daily drinks) and donated a blood sample in 2001–2004. We determined the ADH1B rs1229984 G>A polymorphism and retrieved mortality data from the Western Australian Data Linkage System. Other study measures included age, education, body mass index, smoking, and history of hypertension, diabetes, chronic respiratory diseases, coronary heart disease and stroke. Of the 3496 participants, 225 (6.4 percent) carried the ADH1B rs1229984 G>A polymorphism. Carriers consumed significantly less alcohol than non‐carriers. The adjusted mortality hazard ratio (MHR, 95 percent confidence interval—95%CI) over 8.0 years (range: 10 weeks to 11.2 years) relative to never drinkers was 1.15 (95%CI = 0.86, 1.55) for past drinkers, 0.98 (95%CI = 0.76, 1.25) for men consuming ≤ two daily drinks, 1.13 (95%CI = 0.85, 1.49) for two to four drinks, 1.18 (95%CI = 0.81, 1.71) for four to six drinks and 1.87 (95%CI = 1.11, 3.12) for those consuming more than six daily drinks on a regular basis. The MHR associated with the ADH1B rs1229984 G>A polymorphism was 0.68 (95%CI = 0.54, 0.87). Excessive alcohol use in later life is associated with increased mortality, and this association is likely to be causal. We found no evidence that light to moderate alcohol use decreases the mortality of older men. Health messages regarding the safe use of alcohol in older age may benefit from taking these findings into account.

AB - We designed this cohort study of men aged 70–89 years to determine if excessive alcohol use increases mortality. They reported history of alcohol use (never, past, ≤ two daily drinks, two to four daily drinks, four to six daily drinks, > six daily drinks) and donated a blood sample in 2001–2004. We determined the ADH1B rs1229984 G>A polymorphism and retrieved mortality data from the Western Australian Data Linkage System. Other study measures included age, education, body mass index, smoking, and history of hypertension, diabetes, chronic respiratory diseases, coronary heart disease and stroke. Of the 3496 participants, 225 (6.4 percent) carried the ADH1B rs1229984 G>A polymorphism. Carriers consumed significantly less alcohol than non‐carriers. The adjusted mortality hazard ratio (MHR, 95 percent confidence interval—95%CI) over 8.0 years (range: 10 weeks to 11.2 years) relative to never drinkers was 1.15 (95%CI = 0.86, 1.55) for past drinkers, 0.98 (95%CI = 0.76, 1.25) for men consuming ≤ two daily drinks, 1.13 (95%CI = 0.85, 1.49) for two to four drinks, 1.18 (95%CI = 0.81, 1.71) for four to six drinks and 1.87 (95%CI = 1.11, 3.12) for those consuming more than six daily drinks on a regular basis. The MHR associated with the ADH1B rs1229984 G>A polymorphism was 0.68 (95%CI = 0.54, 0.87). Excessive alcohol use in later life is associated with increased mortality, and this association is likely to be causal. We found no evidence that light to moderate alcohol use decreases the mortality of older men. Health messages regarding the safe use of alcohol in older age may benefit from taking these findings into account.

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DO - 10.1111/adb.12340

M3 - Article

VL - 22

SP - 570

EP - 578

JO - Addiction Biology

JF - Addiction Biology

SN - 1355-6215

IS - 2

ER -