Abstract
Macrophages are cells of the immune system with high plasticity that enables them to carry out a host of different
functions. This enable them to be subverted by many disease processes, particularly cancer. Recent studies have
shown that perturbation of Hck-mediated signalling, which drives macrophage motility, reduces invasive breast cancer
growth by 70%. In this thesis, the Hck inhibitor RK20449 was used to investigate if macrophage motility also aids in
the progression of melanoma. Results show that RK20449 significantly reduces melanoma growth in both a
subcutaneous model as well as an orthotopic epicutaneous model of B16F10 melanoma.
functions. This enable them to be subverted by many disease processes, particularly cancer. Recent studies have
shown that perturbation of Hck-mediated signalling, which drives macrophage motility, reduces invasive breast cancer
growth by 70%. In this thesis, the Hck inhibitor RK20449 was used to investigate if macrophage motility also aids in
the progression of melanoma. Results show that RK20449 significantly reduces melanoma growth in both a
subcutaneous model as well as an orthotopic epicutaneous model of B16F10 melanoma.
| Original language | English |
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| Qualification | Doctor of Philosophy |
| Awarding Institution |
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| Supervisors/Advisors |
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| Award date | 28 May 2025 |
| DOIs | |
| Publication status | Unpublished - 2025 |
Access to Document
- THESIS - DOCTOR OF PHILOSOPHY - NG Isaac Trinstern - 2025_
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