Examining the neuroprotective efficacy of arginine-rich peptides in a traumatic brain injury model

Research output: ThesisDoctoral Thesis

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Abstract

The devastating impact that traumatic brain injury (TBI) has on the individual, society, and economy cannot be understated, especially since there are no clinically available neuroprotective treatments. Cationic arginine-rich peptides (CARPs) are a recently identified class of neuroprotective peptide showing great promise in pre-clinical models of stroke. This thesis examined the neuroprotective efficacy of CARPs in an animal model of TBI. Collectively, the studies demonstrated that a poly-arginine peptide (R18) could reduce functional and histological deficits, and the neuroinflammatory response following TBI. Thus, the findings warrant further investigation into CARPs as a neuroprotective therapeutic for TBI.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Thesis sponsors
Award date11 Apr 2019
DOIs
Publication statusUnpublished - 2019

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