Examining the interseasonal resurgence of respiratory syncytial virus in Western Australia

David Anthony Foley, Linny Kimly Phuong, Joseph Peplinski, Selina Mei Lim, Wei Hao Lee, Asifa Farhat, Cara A Minney-Smith, Andrew C Martin, Ariel O Mace, Chisha T Sikazwe, Huong Le, Avram Levy, Tobias Hoeppner, Meredith L Borland, Briony Hazelton, Hannah C Moore, Christopher Blyth, Daniel K Yeoh, Asha C Bowen

Research output: Contribution to journalArticlepeer-review

25 Citations (Web of Science)

Abstract

BACKGROUND: Following a relative absence in winter 2020, a large resurgence of respiratory syncytial virus (RSV) detections occurred during the 2020/2021 summer in Western Australia. This seasonal shift was linked to SARS-CoV-2 public health measures. We examine the epidemiology and RSV testing of respiratory-coded admissions, and compare clinical phenotype of RSV-positive admissions between 2019 and 2020.

METHOD: At a single tertiary paediatric centre, International Classification of Diseases, 10th edition Australian Modification-coded respiratory admissions longer than 12 hours were combined with laboratory data from 1 January 2019 to 31 December 2020. Data were grouped into bronchiolitis, other acute lower respiratory infection (OALRI) and wheeze, to assess RSV testing practices. For RSV-positive admissions, demographics and clinical features were compared between 2019 and 2020.

RESULTS: RSV-positive admissions peaked in early summer 2020, following an absent winter season. Testing was higher in 2020: bronchiolitis, 94.8% vs 89.2% (p=0.01); OALRI, 88.6% vs 82.6% (p=0.02); and wheeze, 62.8% vs 25.5% (p<0.001). The 2020 peak month, December, contributed almost 75% of RSV-positive admissions, 2.5 times the 2019 peak. The median age in 2020 was twice that observed in 2019 (16.4 vs 8.1 months, p<0.001). The proportion of RSV-positive OALRI admissions was greater in 2020 (32.6% vs 24.9%, p=0.01). There were no clinically meaningful differences in length of stay or disease severity.

INTERPRETATION: The 2020 RSV season was in summer, with a larger than expected peak. There was an increase in RSV-positive non-bronchiolitis admissions, consistent with infection in older RSV-naïve children. This resurgence raises concern for regions experiencing longer and more stringent SARS-CoV-2 public health measures.

Original languageEnglish
Pages (from-to)e7
JournalArchives of Disease in Childhood
Volume107
Issue number3
Early online date25 Aug 2021
DOIs
Publication statusPublished - 1 Mar 2022

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