Abstract
The B cell subsets and protective functions of antibodies that underlie immune-control of HIV-1 infection and vaccine-induced immunity are poorly characterised. This thesis demonstrated that early control of HIV-1 infection was associated with the magnitude of opsonising IgG antibodies that induced phagocytosis of HIV-1 p24 capsid protein by plasmacytoid dendritic cells. The B cell compartment following vaccination was also examined using novel methodology developed here. The quality of vaccine-induced antibody responses was associated with the expansion of phenotypically distinct B cell, plasmablast and circulating follicular helper T cell subsets. These findings have important implications for the rational design of vaccines.
| Original language | English |
|---|---|
| Qualification | Doctor of Philosophy |
| Awarding Institution |
|
| Supervisors/Advisors |
|
| Thesis sponsors | |
| Award date | 20 May 2020 |
| DOIs | |
| Publication status | Unpublished - 2020 |
Access to Document
- TH20 152 THESIS - DOCTOR OF PHILOSOPHY - TJIAM, Mark Christian - 2020
This work is protected by Copyright. You may print or download ONE copy of this document for the purpose of your own non-commercial research or study. Any other use requires permission from the copyright owner. The Copyright Act requires you to attribute any copyright works you quote or paraphrase.