Examination of B cell and IgG antibody responses in vaccination and HIV-1 infection

Research output: ThesisDoctoral Thesis

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Abstract

The B cell subsets and protective functions of antibodies that underlie immune-control of HIV-1 infection and vaccine-induced immunity are poorly characterised. This thesis demonstrated that early control of HIV-1 infection was associated with the magnitude of opsonising IgG antibodies that induced phagocytosis of HIV-1 p24 capsid protein by plasmacytoid dendritic cells. The B cell compartment following vaccination was also examined using novel methodology developed here. The quality of vaccine-induced antibody responses was associated with the expansion of phenotypically distinct B cell, plasmablast and circulating follicular helper T cell subsets. These findings have important implications for the rational design of vaccines.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Fernandez, Sonia, Supervisor
  • French, Martyn, Supervisor
Thesis sponsors
Award date20 May 2020
DOIs
Publication statusUnpublished - 2020

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