This thesis is comprised of two-parts . Part-1 investigates the evolution of Bowman-Birk protease inhibitors building on a discovery in the spikemoss, Selaginella moellendorffii (James et al., 2017a, Plant Cell). Part-11 investigates the action of asparaginyl endopeptidases (AEPs) including :(Ch-4) a review of macrocyclizing AEPs (James et al., 2017b, New Phyt.); (Ch-5) the structure and processing of a seed storage protein by AEP (Franke, James et al., 2017, JBC); (Ch-6) the structural basis for macrocyclization by AEPs (Haywood et al., 2018, eLife); and (Ch-7) the evolutionary constraints restricting complete specialization of AEPs as cyclizing enzymes (James et al. submitted).
|Qualification||Doctor of Philosophy|
|Award date||9 Mar 2018|
|Publication status||Unpublished - 2017|