Evolutionary insights into two plant protein families: Bowman-Birk inhibitors and asparaginyl endopeptidases

Amy Midori James

Research output: ThesisDoctoral Thesis

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Abstract

This thesis is comprised of two-parts . Part-1 investigates the evolution of Bowman-Birk protease inhibitors building on a discovery in the spikemoss, Selaginella moellendorffii (James et al., 2017a, Plant Cell). Part-11 investigates the action of asparaginyl endopeptidases (AEPs) including :(Ch-4) a review of macrocyclizing AEPs (James et al., 2017b, New Phyt.); (Ch-5) the structure and processing of a seed storage protein by AEP (Franke, James et al., 2017, JBC); (Ch-6) the structural basis for macrocyclization by AEPs (Haywood et al., 2018, eLife); and (Ch-7) the evolutionary constraints restricting complete specialization of AEPs as cyclizing enzymes (James et al. submitted).
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Mylne, Josh, Supervisor
  • Bond, Charlie, Supervisor
Award date9 Mar 2018
DOIs
Publication statusUnpublished - 2017

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title = "Evolutionary insights into two plant protein families: Bowman-Birk inhibitors and asparaginyl endopeptidases",
abstract = "This thesis is comprised of two-parts . Part-1 investigates the evolution of Bowman-Birk protease inhibitors building on a discovery in the spikemoss, Selaginella moellendorffii (James et al., 2017a, Plant Cell). Part-11 investigates the action of asparaginyl endopeptidases (AEPs) including :(Ch-4) a review of macrocyclizing AEPs (James et al., 2017b, New Phyt.); (Ch-5) the structure and processing of a seed storage protein by AEP (Franke, James et al., 2017, JBC); (Ch-6) the structural basis for macrocyclization by AEPs (Haywood et al., 2018, eLife); and (Ch-7) the evolutionary constraints restricting complete specialization of AEPs as cyclizing enzymes (James et al. submitted).",
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school = "The University of Western Australia",

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AB - This thesis is comprised of two-parts . Part-1 investigates the evolution of Bowman-Birk protease inhibitors building on a discovery in the spikemoss, Selaginella moellendorffii (James et al., 2017a, Plant Cell). Part-11 investigates the action of asparaginyl endopeptidases (AEPs) including :(Ch-4) a review of macrocyclizing AEPs (James et al., 2017b, New Phyt.); (Ch-5) the structure and processing of a seed storage protein by AEP (Franke, James et al., 2017, JBC); (Ch-6) the structural basis for macrocyclization by AEPs (Haywood et al., 2018, eLife); and (Ch-7) the evolutionary constraints restricting complete specialization of AEPs as cyclizing enzymes (James et al. submitted).

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